Evidence map›Paper›PMID 42214343›Full record

ArticleZeitschrift fur Naturforschung. C, Journal of biosciences2026

Cytotoxicity and antimicrobial activity of platinum(II) complexes based on the ligand precursor 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine - influence of substituent and ancillary ligand on selectivity and activity.

Marian Hebenbrock, Soňa Gurská, Kateřina Bogdanová, Kristýna Rešová, Milan Kolář, Felix Boisten, Marián Hajdúch, Petr Džubák, Jens Müller

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Article in Zeitschrift fur Naturforschung. C, Journal of biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marian HebenbrockInstitute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany.ORCID https://orcid.org/0000-0002-9339-5165
Soňa GurskáFaculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University and University Hospital Olomouc, Hněvotínská 1333/5, 779 00, Olomouc, Czech Republic.
Kateřina BogdanováDepartment of Microbiology, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic.
Kristýna RešováDepartment of Microbiology, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic.
Milan KolářDepartment of Microbiology, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic.
Felix BoistenInstitute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany.
Marián HajdúchFaculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University and University Hospital Olomouc, Hněvotínská 1333/5, 779 00, Olomouc, Czech Republic.
Petr DžubákFaculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University and University Hospital Olomouc, Hněvotínská 1333/5, 779 00, Olomouc, Czech Republic.
Jens MüllerInstitute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, 48149 Münster, Germany.ORCID https://orcid.org/0000-0003-4713-0606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of metal-based anticancer agents has been a significant area of research since the discovery of cisplatin's cytostatic effects. In this study, we investigate the cytotoxicity of tridentate ligands derived from 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine and their platinum(II) and palladium(II) complexes against various human cancer cell lines and normal fibroblasts. Several complexes exhibit high cytotoxicity, particularly against acute T-lymphoblastic leukemia cells (CCRF-CEM). Notably, a platinum(II) complex containing an acylpyrrolidine ligand demonstrates remarkable cancer cell selectivity with a sub-micromolar IC

Indexed as

cytotoxicitymetalationplatinum(II) complexestridentate ligands

Identifiers

PMID42214343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.