Evidence map›Paper›PMID 42214339›Full record

ArticleMed (New York, N.Y.)2026

First human decedent model of orthotopic multi-organ xenotransplantation: Whole liver and bilateral kidneys from a six-gene-edited pig.

Jixiang Liao, Sanqi An, Jianhui Dong, ShihJung Li, Jianhui Li, Lei Dong, Ziyang Luo, Liugen Lan, Ning Wen, Jihua Wu and 25 more

Abstract read
PubMed Publisher
In one paragraph

Article in Med (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Jixiang LiaoInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Sanqi AnGuangxi Key Laboratory of AIDS Prevention and Treatment, Life Sciences Institute, Guangxi Medical University, Nanning 530020, China.
Jianhui DongInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
ShihJung LiInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Jianhui LiPollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang 310015, China.
Lei DongLaboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210093, China.
Ziyang LuoInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Liugen LanInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Ning WenInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Jihua WuInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Jiqiu WenInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Zhiying LeiInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Dongge YangInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Haibin LiInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Minghu LiInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Yan MoDepartment of Pathology, Yulin Campus, Guangxi Medical University, Yulin, Guangxi 537000, China.
Luying ChenYulin Campus, Guangxi Medical University, Yulin, Guangxi 537000, China.
Zhao GaoInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Xuyang LiuInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Haisong QinGuangxi Key Laboratory of AIDS Prevention and Treatment, Life Sciences Institute, Guangxi Medical University, Nanning 530020, China.
Xiang WangInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Yajing ChenInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China.
Wenli YinDepartment of Genetics and Metabolism, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530003, China.
Bihui HuangThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Wenxing LiDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.
Gabriel OniscuDepartment of Clinical Science, Intervention and Technology Karolinska Institute, Stockholm, Sweden.
Wenshi JiangInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China; China Organ Donation Administrative Center, Beijing, China.
Dengke PanXenotransplantation and Regeneration Key Laboratory of Sichuan Province, Chengdu ClonOrgan Biotechnology Co., Ltd., Chengdu, China; Chengdu ClonOrgan Biotechnology Co., Ltd., Chengdu, China.
Zhengxin WangLiver Transplantation Center, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Zhijun ZhuLiver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Jinzhen CaiOrgan Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China.
Haitao LiState Key Laboratory of Molecular Oncology, MOE Key Laboratory of Protein Sciences, Beijing Frontier Research Center for Biological Structure, School of Medicine, Tsinghua University, Beijing 100084, China.
Juntao GaoMOE Key Laboratory of Bioinformatics, Bioinformatics Division, Center for Synthetic & Systems Biology, BNRist, Center for Synthetic & Systems Biology, Tsinghua University, Beijing 100084, China.
Xiaocong KuangSchool of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: kuangxiaocong@gxmu.edu.cn.
Xuyong SunInstitute of Transplant Medicine, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Organ Donation and Transplantation, Nanning 530007, China. Electronic address: sunxuyong@gxmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe report orthotopic combined whole-liver and bilateral-kidney xenotransplantation (xeno-CLKT) from a six-gene-edited pig into a 53-year-old human decedent recipient.

methodsAfter simultaneous implantation and reperfusion, graft function was monitored for nearly 5 days using continuous clinical assessments. Host responses were further characterized with single-cell RNA sequencing, proteomics, and metabolomics of blood and graft tissues collected before and after transplantation.

findingsAll grafts maintained basic physiological function throughout the observation period, with no evidence of hyperacute rejection. Early post-transplant immune analysis showed expansion of S100A12

conclusionsThis study provides initial evidence for the feasibility of pig-to-human orthotopic whole-liver plus bilateral-kidney transplantation and identifies early immune and metabolic features that may inform perioperative management and future clinical translation.

fundingThe research was supported by the Guangxi Key Research and Development Program (AB24010059), the Shenzhen Medical Research Fund (SMAF) (B2302008), and the Guangdong Province Guangdong-Shenzhen Joint Key Project (2023B1515120083).

Indexed as

Kidney TransplantationLiver TransplantationTransplantation, HeterologousAnimalsAnimals, Genetically ModifiedGraft SurvivalHumansLiverMaleMetabolomicsMiddle AgedModels, AnimalSwinedeceased humanimmune landscapemetabolomic profilesix-gene-edited pigtranslation to humansxenogeneic combined liver and kidney transplantation

Identifiers

PMID42214339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.