Evidence map›Paper›PMID 42214331›Full record

ArticleMolecular cell2026

Molecular mechanisms of the MLL4 complex in H3K4 methylation and p53-dependent transcription activation.

Jianfeng Sun, Zhiying Zhang, You Yu, Nicole Cruz, Sicong Zhang, Yufei Xiang, Keiichi Ito, Cole Lazarus, Zhanyun Tang, Buren Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jianfeng SunLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: jsun01@rockefeller.edu.
Zhiying ZhangStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
You YuStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department for Cardiology of the Second Affiliated Hospital, Center for Infection Immunity, Cancer of Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
Nicole CruzLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Sicong ZhangLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Yufei XiangCenter of Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Keiichi ItoLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Cole LazarusDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Zhanyun TangLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Buren LiStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Douglas BarrowsBioinformatics Resource Center, The Rockefeller University, New York, NY, USA.
Tom W MuirDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Yi ShiCenter of Protein Engineering and Therapeutics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Dina Schneidman-DuhovnySchool of Computer Science and Engineering, the Hebrew University of Jerusalem, Jerusalem, Israel.
Shu-Ping WangInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Linas UrnaviciusLaboratory of Chemistry and Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: lurnaviciu@rockefeller.edu.
Dinshaw J PatelStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: pateld@mskcc.org.
Robert G RoederLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: roeder@rockefeller.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Structure, Function and Applications of InteinsR01GM086868 · NIGMS · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2008 to 2025
$4.4M
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin stateR01CA259365 · NCI · DANA-FARBER CANCER INST · PI Cigall Kadoch, Tom Muir · 2021 to 2026
$4.2M
Molecular mechanisms of estrogen receptor-dependent transcription regulationR01CA234575 · NCI · ROCKEFELLER UNIVERSITY · PI ROEDER, ROBERT G · 2019 to 2023
$3.1M
Mapping the Dynamic Interactome of Ig-fold Membrane Proteins Using Nanobody-Based ToolsR35GM137905 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yi Shi · 2020 to 2026
$2.8M
Mechanistic studies of transcription initiation and elongation functions of an RNA polymerase II variant, Pol II(G), that is implicated in development and cancerR01CA273709 · NCI · ROCKEFELLER UNIVERSITY · PI ROBERT G ROEDER · 2022 to 2026
$1.9M
Mechanisms of transcriptional control of adipocyte formation and function through nuclear receptor coactivatorsR01DK144459 · NIDDK · ROCKEFELLER UNIVERSITY · PI ROBERT G ROEDER · 2025 to 2026
$1.5M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA234575NCI NIH HHS R01 CA259365NCI NIH HHS R01 CA273709NIDDK NIH HHS R01 DK144459NIGMS NIH HHS R01 GM086868NIGMS NIH HHS R35 GM137905
6 · The paper itself

Abstract

Mammalian H3K4 mono-methyltransferase MLL4 plays a critical role in enhancer-mediated gene activation. Here, we utilized a reconstituted MLL4 "fusion" complex (MLL4

Indexed as

DNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesTranscriptional ActivationTumor Suppressor Protein p53ChromatinHCT116 CellsHumansIntracellular Signaling Peptides and ProteinsMethylationNuclear ProteinsProtein BindingTranscription FactorsASH2L protein, humanChromatinDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesIntracellular Signaling Peptides and ProteinsMLL4 protein, humanNuclear ProteinsRBBP5 protein, humanTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53WDR5 protein, humancoactivator synergyepigenetic crosstalkH3K4 methylationMLL4nucleosome bindingp53transcriptional regulation

Identifiers

PMID42214331
PMCPMC13502306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.