Designed Synthesis of Unsymmetrical (Deuterated) 1,1-Diarylethylenes via Simple Sequential Coupling of Arenes and Aldehydes.

Nicole Hanania, Rafael Snyder, Amit Garti, Ahmad Masarwa

Abstract read

In one paragraph

Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Designed Synthesis of Unsymmetrical (Deuterated) 1,1-Diarylethylenes via Simple Sequential Coupling of Arenes and Aldehydes.The Journal of organic chemistry · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole HananiaInstitute of Chemistry, The Center for Nanoscience and Nanotechnology, and Casali Center for Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401,Israel.

Rafael SnyderInstitute of Chemistry, The Center for Nanoscience and Nanotechnology, and Casali Center for Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401,Israel.

Amit GartiInstitute of Chemistry, The Center for Nanoscience and Nanotechnology, and Casali Center for Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401,Israel.

Ahmad MasarwaInstitute of Chemistry, The Center for Nanoscience and Nanotechnology, and Casali Center for Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401,Israel.ORCID 0000-0001-6992-5595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A practical and efficient method for synthesizing unsymmetrical (deuterated) 1,1-diarylethylenes is reported. The strategy relies on simple and selective sequential coupling processes in which (1) commercially available arenes react with aldehydes to form benzhydrylphosphonium salts in a regioselective manner, (2) followed by a chemoselective Wittig-type olefination with (deuterated) formaldehyde. This approach affords (deuterated) 1,1-diarylethylenes in good yields with high levels of isotopic incorporation. This protocol provides straightforward access to versatile building blocks of interest for synthetic and medicinal applications.

Identifiers

PMID42213864

DOI10.1021/acs.joc.6c00935

PMCPMC13270521

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.