Evidence map›Paper›PMID 42213854›Full record

ArticleScience advances2026

CEMs-SELEX: DNAzyme-powered de novo biomarker discovery and noninvasive cancer diagnosis.

Wei Cui, Hang Xiao, Xiaohong Wen, Chen Li, Suxia Bao, Ying Long, Xiaohai Yang, Kemin Wang, Qiuping Guo, Jin Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei CuiState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0000-0002-5937-0343
Hang XiaoState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0009-0007-3390-3141
Xiaohong WenXiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, P. R. China.ORCID 0009-0003-7408-4155
Chen LiState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0009-0000-0801-3971
Suxia BaoState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0009-0009-1749-1305
Ying LongHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, P. R. China.ORCID 0000-0003-0559-3012
Xiaohai YangState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0000-0001-8122-7140
Kemin WangState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0000-0001-9390-4938
Qiuping GuoState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0000-0003-2092-6639
Jin HuangState Key Laboratory of Chemo and Biosensing, Hunan University, Changsha 410082, China.ORCID 0000-0002-2890-682X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to interrogate complex biological environments without prior target knowledge is a key challenge in chemical sensing. Conventional methods are limited in discovering previously unidentified biomarkers. To overcome this, we developed CEMs-SELEX (cell extracellular mixtures-systematic evolution of ligands by exponential enrichment), a de novo selection platform that screens for functional DNAzymes responsive to disease-specific CEMs. Applied to tongue squamous cell carcinoma (TSCC), we identified C502, a DNAzyme activated by tumor secretions with high affinity (

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellDNA, CatalyticSELEX Aptamer TechniqueTongue NeoplasmsAnnexin A2Cell Line, TumorHumansMolecular Docking SimulationAnnexin A2ANXA2 protein, humanBiomarkers, TumorDNA, Catalytic

Identifiers

PMID42213854
PMCPMC13220889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.