Evidence map›Paper›PMID 42213839›Full record

ArticleScience advances2026

Structural insights into a conserved mechanism of choline translocation through CHT.

Jesus Vilchez-Garcia, Adrián Martínez-Jiménez, Hanxing Jiang, Miguel Luengo, Borja Ochoa-Lizarralde, Jorge Pedro López-Alonso, Jerónimo Pérez-Lorente, Paola Bartoccioni, Raúl Estévez, Victor Guallar and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jesus Vilchez-GarciaInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.ORCID 0000-0002-2696-695X
Adrián Martínez-JiménezPhysiological Sciences Department, Institute of Neurosciences, School of Medicine and Health Sciences, University of Barcelona, Bellvitge Campus, L'Hospitalet de Llobregat, Spain.ORCID 0009-0004-5425-2630
Hanxing JiangInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.
Miguel LuengoElectronic and Atomic Protein Modelling Group, Barcelona Supercomputing Center, Plaça d'Eusebi Güell, 1-3, E-08034 Barcelona, Spain.ORCID 0000-0001-7501-3576
Borja Ochoa-LizarraldeInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.ORCID 0000-0002-5532-0218
Jorge Pedro López-AlonsoInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.ORCID 0000-0003-2081-2607
Jerónimo Pérez-LorenteInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.ORCID 0009-0005-8965-0281
Paola BartoccioniInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, E-08028 Barcelona, Spain.ORCID 0000-0001-8835-8450
Raúl EstévezPhysiological Sciences Department, Institute of Neurosciences, School of Medicine and Health Sciences, University of Barcelona, Bellvitge Campus, L'Hospitalet de Llobregat, Spain.ORCID 0000-0003-1579-650X
Victor GuallarElectronic and Atomic Protein Modelling Group, Barcelona Supercomputing Center, Plaça d'Eusebi Güell, 1-3, E-08034 Barcelona, Spain.ORCID 0000-0002-4580-1114
Ekaitz Errasti-MurugarrenPhysiological Sciences Department, Institute of Neurosciences, School of Medicine and Health Sciences, University of Barcelona, Bellvitge Campus, L'Hospitalet de Llobregat, Spain.ORCID 0000-0002-6054-7900
Iban Ubarretxena-BelandiaInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.ORCID 0000-0003-4082-4349
Igor TascónInstituto Biofisika (UPV/EHU-CSIC), Leioa, Spain.ORCID 0000-0003-2526-6238

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choline is an essential nutrient critical for cellular homeostasis across all domains of life. In humans, choline uptake in cholinergic neurons for its recycling into acetylcholine is mediated by the high-affinity Na

Indexed as

CholineMembrane Transport ProteinsSymportersBiological TransportCryoelectron MicroscopyHumansModels, MolecularProtein ConformationSodiumCholinecholine transporterMembrane Transport ProteinsSodiumSymporters

Identifiers

PMID42213839
PMCPMC13220886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.