Evidence map›Paper›PMID 42213833›Full record

ArticleScience advances2026

Lymph node-targeted DNA engages TBK1/IFN-I-driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs.

Martin P Steinbuck, Lochana M Seenappa, Wei Zhan, Erica Palmer, Mimi M Jung, Aniela Jakubowski, Xavier Cabana-Puig, Lisa K McNeil, Christopher M Haqq, Katherine A Fitzgerald and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Martin P SteinbuckElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0000-0001-5599-8953
Lochana M SeenappaElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0000-0003-0543-5495
Wei ZhanProgram in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-9769-4632
Erica PalmerElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0009-0003-2469-1723
Mimi M JungElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0009-0002-1693-3860
Aniela JakubowskiElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0000-0002-3805-9855
Xavier Cabana-PuigElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0000-0001-9929-7307
Lisa K McNeilElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.
Christopher M HaqqElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0000-0001-8600-9548
Katherine A FitzgeraldProgram in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0003-3175-609X
Peter C DeMuthElicio Therapeutics, 451 D Street, 5th Floor, Suite 501, Boston, MA 02210, USA.ORCID 0000-0002-7044-7559

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adjuvants are immunoactivators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses. Here, we engineered a class of Amphiphile (AMP)-modified, immunostimulatory DNA adjuvants designed for targeted delivery to lymph nodes and enhanced stimulation of TANK-binding kinase 1 (TBK1)-mediated danger-sensing pathways to generate strong adaptive immunity and long-term memory with potent recall potential. AMP-DNA adjuvants induced robust interferon type-I (IFN-I)-driven inflammatory environments in mouse and nonhuman primate (NHP) lymph nodes, leading to significantly enhanced cytokine secretion by polyfunctional CD8

Indexed as

DNAImmunity, InnateImmunologic MemoryInterferon Type ILymph NodesProtein Serine-Threonine KinasesT-LymphocytesAdjuvants, ImmunologicAnimalsFemaleMiceAdjuvants, ImmunologicDNAInterferon Type IProtein Serine-Threonine KinasesTbk1 protein, mouse

Identifiers

PMID42213833
PMCPMC13220859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.