ArticleScience advances2026
Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle-mediated infection in humanized liver chimeric mouse models.
Seung Bum Park, Jaime Sánchez-Meza, Regina Umarova, Justin Shields, Laura Collignon, Xhuliana Sula, Kenn Holmbeck, Ji Hoon Oh, Patrizia Farci, D Lorne Tyrrell and 4 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Seung Bum ParkLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2834-9071 Jaime Sánchez-MezaLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.
Regina UmarovaLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0009-3842-3942 Justin ShieldsLi Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-4701-4576 Laura CollignonCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5805-4859 Xhuliana SulaCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kenn HolmbeckCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4472-3257 Ji Hoon OhLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-0824-6131 Patrizia FarciHepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
D Lorne TyrrellLi Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-0983-7267 Jordan J FeldToronto Centre for Liver Disease, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-2640-2211 Jens BukhCopenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7815-4806 Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-3087-8079 T Jake LiangLiver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3828-702X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
A major challenge in hepatitis C virus (HCV) research is the lack of an in vivo model that supports robust infection, antiviral testing, and vaccine development. The humanized liver chimeric mouse models support high-level viremia from various HCV sources, although they lack an immune system. Here, we used
Indexed as
HepacivirusHepatitis CLipidsLiverNanoparticlesAnimalsAntiviral AgentsDisease Models, AnimalHepatocytesHumansInterleukin Receptor Common gamma SubunitLiposomesMiceMice, KnockoutMice, SCIDRNA, ViralAntiviral AgentsInterleukin Receptor Common gamma SubunitLipid NanoparticlesLipidsLiposomesRNA, Viral
Identifiers
PMID42213828
PMCPMC13220863
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