ArticleACS biomaterials science & engineering2026
Composition Matters: Collagen vs Polyacrylamide Modulates Distinct Trabecular Meshwork Cell Traction.
Article in ACS biomaterials science & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Segmental flow responses in glaucomatous trabecular meshwork cells.Biomaterials advances · 2026Article
- Differential Cytoskeletal Control of Cell-Collagen Mechanics in High- and Low-Flow Glaucomatous Trabecular Meshwork Cells.ACS applied materials & interfaces · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cells actively sense not only substrate stiffness but also matrix architecture and composition. To understand how these factors play a role in mechanobiology while minimizing stiffness as a dominant variable, we cultured normal high-flow human trabecular meshwork (TM) cells on a fibrous type I collagen gel and a collagen-coated polyacrylamide (PAM) gel (nominal stiffness ∼4.7 kPa for PAM; collagen fiber stiffness characterized by atomic force microscopy (AFM)) but with distinct microstructures, including a fibrous, elastic/viscoelastic type I collagen gel and an amorphous, linearly/non-linearly elastic polyacrylamide (PAM) gel. Using live 3D traction force microscopy and a traction-release (trypsin detachment) assay, we quantified cell-induced displacement fields and computed traction force distributions, strain, divergence (∇·
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Registered trials
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