Evidence map›Paper›PMID 42213732›Full record

ArticleBrain and behavior2026

Sleep Traits and Cognitive Function: A Prospective Cohort Study With Exploration of Inflammatory Biomarkers.

Chi Peng, Fan Yang, Fanfan Li, Ronghui Zhu, Lei Li, Zhentao Zhang, Jianyao You, Rui Wang, Yingyi Qin, Shuogui Xu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chi PengDepartment of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.
Fan YangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Army Medical University, Chongqing, China.
Fanfan LiDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Ronghui ZhuDepartment of Health Statistics, Naval Medical University, Shanghai, China.
Lei LiDepartment of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhentao ZhangDepartment of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.
Jianyao YouDepartment of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.
Rui WangDepartment of Health Statistics, Naval Medical University, Shanghai, China.
Yingyi QinDepartment of Health Statistics, Naval Medical University, Shanghai, China.
Shuogui XuDepartment of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.

Funding

Medical Science and Technology Innovation Project of Xuzhou Municipal Health Commission XWKYHT20240054National Key Research and Development Program of ChinaResearch Project of Shanghai Municipal Health Statistics Center.
6 · The paper itself

Abstract

introductionAlthough sleep disturbance is closely linked to cognitive impairment, the specific sleep-related characteristics driving this deficit remain undetermined, with the mechanistic contribution of biomarkers also poorly characterized. Accumulating evidence suggests that inflammation may contribute to cognitive decline, yet its mediating role in the sleep-cognition relationship has not been fully clarified.

methodsBased on the UK Biobank, four linear regression models (for reasoning, reaction time, visual memory, and numeric memory) and one logistic regression model (for prospective memory) were employed to analyze the relation between sleep features and cognitive impairment. Apart from that, the bootstrap mediation model and Mendelian randomization were utilized to investigate the causal association.

resultsShort sleep duration (β = -0.394, p = 0.020) and long sleep duration (β = -0.359, p = 0.014) correlated with poorer numeric memory performance, while moderate sleep quality (β = -0.071, p = 0.042) and work shift were linked to impaired reasoning, reaction time, visual memory, and prospective memory. Subgroup analyses stratified by age, sex, and BMI further supported these associations. In addition, C-reactive protein (CRP) partially mediated the snoring-reasoning ability association (PM: β = -0.071, p = 0.049), with MR analysis confirming a causal pathway, whereas snoring elevated CRP levels to impair reasoning, accounting for 32.1% of the observed relationship.

conclusionIn this cohort study, abnormal sleep traits correlated with domain-specific cognitive impairments, with CRP partially mediating the snoring-reasoning association.

Indexed as

CognitionCognitive DysfunctionInflammationSleepAgedBiomarkersC-Reactive ProteinFemaleHumansMaleMemoryMiddle AgedProspective StudiesSleep DurationSleep QualityBiomarkersC-Reactive Proteincognitive impairmentmediation analysisMendelian randomization analysissleep traitswork shift

Identifiers

PMID42213732
PMCPMC13240425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.