ArticleAmerican journal of physiology. Renal physiology2026
Transcriptomics of S3 segment in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism.
Young Chul Kim, Chen Meng, Sadhana Kanoo, Scott Thomson, Anil Karihaloo, Volker Vallon
Abstract read
In one paragraphArticle in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Young Chul KimDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, United States.ORCID 0000-0002-6782-2186 Chen MengNovo Nordisk A/S, Måløv, Denmark.
Sadhana KanooDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, United States.
Scott ThomsonDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, United States.ORCID 0000-0001-8853-0505 Anil KarihalooNovo Nordisk, Lexington, Massachusetts, United States.
Volker VallonDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, United States.ORCID 0000-0002-9211-2063 Funding
UAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Javier A. Neyra · 2023 to 2026
$4.4MGlomerular and Tubular Function in the Diabetic KidneyR01DK112042 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SCOTT Culver THOMSON, Volker Vallon · 2017 to 2026
$4.1MResource-based Center for the study of the joint microenvironment in rheumatology (Overall Application)P30AR073761 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CORR, MARY P · 2018 to 2022
$3.9MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK112042HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54DK137307NIAMS NIH HHS P30 AR073761NIDDK NIH HHS R01 DK112042NIDDK NIH HHS U54 DK137307NIH HHS S10 OD026929
6 · The paper itselfAbstract
Inhibitors of SGLT2 (SGLT2is) and diabetes enhance glucose delivery and reabsorption in late proximal tubule S3 segments. Molecular consequences remain poorly understood. Here, we determined transcriptomic changes in S3 segments of male adult DBA wild-type (WT) and littermate diabetic Akita mice ± Sglt1 knockout (Sglt1-KO) given vehicle or SGLT2i dapagliflozin for 2 wk, and in Akita mice receiving glucagon-like peptide-1 receptor (GLP1R) agonist (GLP1RA) semaglutide. RNA sequencing was performed in S3 segments isolated by immunostaining-guided laser-capture-microdissection in deep cortex/outer medulla. Among 19,068 detected annotated genes, 838 genes were differentially expressed by SGLT2is in WT (differentially expressed genes; DEGs;
Indexed as
Diabetes Mellitus, Type 1Glucagon-Like Peptide-1 Receptor AgonistsKidney Tubules, ProximalSodium-Glucose Transporter 2 InhibitorsTranscriptomeAnimalsBlood GlucoseCell ProliferationDisease Models, AnimalGene Expression ProfilingGlucagon-Like Peptide-1 ReceptorGlucagon-Like PeptidesMaleMiceMice, KnockoutSemaglutideBlood GlucoseGlp1r protein, mouseGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsGlucagon-Like PeptidesSemaglutideSlc5a1 protein, mouseSlc5a2 protein, mouseSodium-Glucose Transporter 1Sodium-Glucose Transporter 2Sodium-Glucose Transporter 2 InhibitorsGLP1 receptor agonistlate proximal tubuleRNA-seqSGLT1SGLT2 inhibitor
Identifiers
PMID42213650
PMCPMC13339211
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