ArticleBrain and behavior2026
Exploring the Causality Between Mood Swings and Neurological Diseases: A Mendelian Randomization Study.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAssociations between genetically predicted mood swings and neurological diseases have been suggested. However, the causal relationships between these factors remain undefined.
methodWe used a Mendelian randomization (MR) study to examine the causal relationship of genetically predicted mood swings with the risk of neurological diseases, including stroke, Alzheimer's disease (AD), multiple sclerosis (MS), epilepsy (EP), and headache. The single-nucleotide polymorphisms (SNPs) that exhibited genetic associations with mood swings were utilized as instrumental variables (IV) in the study. We performed MR analyses using the inverse variance weighted (IVW) method as the main approach. Sensitivity analyses were further performed using MR-Egger and MR-PRESSO to assess the robustness.
resultsThe MR analysis revealed significant causal of mood swings on stroke (OR = 1.300, 95% CI = 1.060-1.600; p = 0.012), headache (OR = 1.020, 95% CI = 1.000-1.030; p = 0.005), excluding AD (p = 0.548), EP (p = 0.449), MS (p = 0.494).
conclusionThe findings of this research indicate a possible causal link existing between mood swings and stroke and headache. Additional investigative efforts are requisite for elucidating the underlying biological mechanisms that drive these observed associations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.