Evidence map›Paper›PMID 42213614›Full record

ArticleRespiration; international review of thoracic diseases2026

Nocturnal Hypoxaemia in PAH Patients Living at High Altitude Relocated to Low Altitude.

Esther I Schwarz, Joël J Herzig, Meret Bauer, Elizabeth Cajamarca, Michael Furian, Mona Lichtblau, Julian Mueller, Diego Saragoni, Stephanie Saxer, Mirjam Schmucki and 3 more

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In one paragraph

Article in Respiration; international review of thoracic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Esther I SchwarzDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Joël J HerzigDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Meret BauerDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Elizabeth CajamarcaHospital Carlos Andrade Marin, Quito, Ecuador.
Michael FurianDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Mona LichtblauDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Julian MuellerDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Diego SaragoniDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Stephanie SaxerDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Mirjam SchmuckiDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Simon R SchneiderDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Rodrigo HoyosHospital Carlos Andrade Marin, Quito, Ecuador.
Silvia UlrichDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland, silvia.ulrich@usz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients with pulmonary arterial hypertension (PAH) living at high altitudes experience exacerbated hypoxaemia. This study aimed to assess the effects of relocating PAH patients from high altitude (2,850 m) to sea level on nocturnal hypoxaemia, sleep-disordered breathing, and autonomic cardiovascular function.

methodsIn a repeated measures design, PAH patients underwent evaluations near their living altitude at 2,850 m and at sea level. The primary outcome was the change in mean nocturnal SpO

resultsA total of 8 patients (86% women) with a mean mean pulmonary artery pressure of 52 ± 17 mm Hg and PVR of 16.6 ± 8.8 Wood units were included. Relocation to sea level resulted in significant improvements in nocturnal hypoxaemia, with mean SpO

conclusionRelocation of PAH patients from high to low altitude led to significant improvements in nocturnal oxygenation and SDB, and enhanced parasympathetic activity, suggesting that short-term exposure to sea level may offer benefits for PAH-patients living at high altitude.

Indexed as

AltitudeHypoxaemiaPulmonary arterial hypertensionPulmonary vascular diseaseSleep-disordered breathing

Identifiers

PMID42213614
PMCPMC13395386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.