Evidence map›Paper›PMID 42213391›Full record

ArticleProbiotics and antimicrobial proteins2026

Blautia Coccoides CML164 Improved Lipid and Energy Metabolism in Broiler Chickens Via Gut Microbiota Pathways.

Zhouyang Gao, Xiaohang Yang, Muying Nie, Suxin Shi, Gaoxiang Yuan, Xiaoyi Li, Yuying Zhang, Dan Liu

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhouyang GaoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Xiaohang YangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Muying NieState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Suxin ShiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Gaoxiang YuanState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Xiaoyi LiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yuying ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Dan LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. liud@cau.edu.cn.

Funding

National Key Research and Development Program of China 2022YFD1300400
6 · The paper itself

Abstract

The probiotic potential of Blautia coccoides CML164, a novel acetate-producing strain isolated from the poultry gut, was systematically evaluated for its ability to modulate lipid and energy metabolism in broilers via gut microbiota-mediated pathways. Supplementation with Blautia coccoides CML164 significantly reshaped the cecal microbiome, enriching beneficial short-chain fatty acid (SCFA)-producing bacteria such as Phocaeicola vulgatus, Parabacteroides distasonis, and members of Prevotellaceae, while concurrently increasing cecal acetate concentration in broiler chickens. These microbial changes were accompanied by improved mitochondrial function, enhanced hepatic fatty acid oxidation (upregulation of PPARα, ACOX1), and suppression of lipogenic genes (SREBP1, PPARγ), leading to reduced abdominal fat deposition and improved serum lipid profiles without compromising growth performance in broilers. The study demonstrates that Blautia coccoides CML164 functions as an effective probiotic by orchestrating gut microbiota composition and promoting SCFA production, thereby activating host metabolic pathways that mitigate lipid accumulation. Our findings highlight the critical role of microbial intervention in regulating energy homeostasis and offer a promising strategy for leveraging probiotics to enhance metabolic health in poultry production.

Indexed as

ChickensEnergy MetabolismGastrointestinal MicrobiomeLipid MetabolismProbioticsAnimalsBacteriaCecumFatty Acids, VolatileFatty Acids, VolatileBlautia coccoides CML164Broiler chickensEnergy metabolismGut microbiotaLipid metabolismProbiotic

Identifiers

PMID42213391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.