Evidence map›Paper›PMID 42213355›Full record

ArticleJournal of hematopathology2026

Oral manifestations of anaplastic large cell lymphoma: clinicopathological features and main immunophenotypic findings of 3 cases.

Carla Isabelly Rodrigues-Fernandes, Isabela Assis de Siqueira, Cinthia Veronica Bardález López de Cáceres, Juan Manuel Arteaga Legarrea, Victor Tieghi Neto, Geovana Martins Lopes, Marcelo Cavalcanti da Cruz, Hélder Antônio Rebelo Pontes, Wilson Delgado-Azañero, Guilherme Rossi Assis de Mendonça and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carla Isabelly Rodrigues-FernandesOral Pathology Unit, Department of Clinic and Preventive Dentistry, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Isabela Assis de SiqueiraDepartment of Dentistry, Department of Pathology, Department of Hematology - Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Cinthia Veronica Bardález López de CáceresDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Juan Manuel Arteaga LegarreaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Victor Tieghi NetoDepartment of Dentistry, Department of Pathology, Department of Hematology - Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Geovana Martins LopesDepartment of Dentistry, Department of Pathology, Department of Hematology - Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Marcelo Cavalcanti da CruzDepartment of Dentistry, Department of Pathology, Department of Hematology - Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
Hélder Antônio Rebelo PontesService of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.
Wilson Delgado-AzañeroDepartamento de Patología, Medicina y Cirugía Oral, Facultad de Estomatología, Universidad Peruana Cayetano Heredia, Lima, Perú.
Guilherme Rossi Assis de MendonçaDepartment of Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Pablo Agustin VargasOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Fábio Luiz CoracinDepartment of Dentistry, Department of Pathology, Department of Hematology - Barretos Cancer Hospital, Barretos, São Paulo, Brazil. fl.coracin@gmail.com.
Felipe Paiva FonsecaDepartment of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. felipepfonseca@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaplastic large cell lymphoma (ALCL) is contained within a larger category of aggressive mature T-cell lymphomas. Their subclassification relies on the presence or absence of Anaplastic Lymphoma Kinase (ALK) gene fusions and other molecular alterations. Cases in the head and neck and mouth are uncommon. The aim of this manuscript is to describe the clinicopathological and immunohistochemical features of a series of anaplastic large cell lymphoma (ALCL) affecting the oral cavity. Three cases are included in this series, all of them affecting male patients, with a mean age of 27.7 years old. Concomitant involvement of the oral cavity and lymph nodes was known to occur in two cases, while cutaneous lesions were not recorded in any patient. The neoplasms more often presented as solitary or multiple painful swellings in the gingiva. All cases were positive for CD30 expression, and the two cases investigated for CD3 were negative. ALK protein was expressed in two cases, and it was negative in one case. EBER was negative in the two cases investigated. One patient was known to decease despite chemotherapy. In conclusion, oral manifestations of ALCL are very rare and more commonly represent a disseminated disease.

Indexed as

Lymphoma, Large-Cell, AnaplasticMouth NeoplasmsAdultAnaplastic Lymphoma KinaseHumansImmunohistochemistryImmunophenotypingKi-1 AntigenMaleReceptor Protein-Tyrosine KinasesALK protein, humanAnaplastic Lymphoma KinaseKi-1 AntigenReceptor Protein-Tyrosine KinasesAnaplastic cell lymphomaAnaplastic lymphoma kinaseMouthNon-Hodgkin lymphoma

Identifiers

PMID42213355
PMCPMC13221397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.