Evidence map›Paper›PMID 42213332›Full record

ArticleEuropean journal of epidemiology2026

Adiposity and the risk of aortic aneurysm: results from the UK Biobank, Japan-Specific Health Check-ups Study and a systematic review and meta-analysis of cohort studies.

Dagfinn Aune, Yoichiro Otaki, Yahya Mahamat-Saleh, Makoto Hibino, Alicia K Heath, Antonio Berlanga-Taylor, Tsuneo Konta, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya and 11 more

Abstract read
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In one paragraph

Article in European journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, 90 Wood Lane, London, W12 0BZ, UK. d.aune@imperial.ac.uk.ORCID http://orcid.org/0000-0002-4533-1722
Yoichiro OtakiDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Yahya Mahamat-SalehNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
Makoto HibinoDivision of Cardiothoracic Surgery, Department of Surgery, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Alicia K HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, 90 Wood Lane, London, W12 0BZ, UK.
Antonio Berlanga-TaylorDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, 90 Wood Lane, London, W12 0BZ, UK.
Tsuneo KontaDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Kunihiro YamagataSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Shouichi FujimotoSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Kazuhiko TsuruyaSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Ichiei NaritaSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Masato KasaharaSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Yugo ShibagakiSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Kunitoshi IsekiSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Toshiki MoriyamaSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Masahide KondoSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Koichi AsahiSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Tsuyoshi WatanabeSteering Committee of Research on Design of the Comprehensive Health Care System for Chronic Kidney Disease Based on Individual Risk Assessment by Specific Health Check, Fukushima, Japan.
Tetsu WatanabeDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Masafumi WatanabeDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Imre JanszkyDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

Norwegian South-East Regional Health Authority 2017076
6 · The paper itself

Abstract

Overweight and obesity has been associated with increased risk of aortic aneurysm in some cohort studies, however, results have been inconsistent. To clarify this association we analysed data from two large cohort studies with a total of > 1.1 million participants, and conducted a systematic review and meta-analysis of published cohort studies. The analytical cohorts included 495,438 participants in UK Biobank and 630,841 participants in the Japan Specific Health Checkups (J-SHC) Study. Multivariable Cox proportional hazards regression models were used to analyse associations between anthropometric factors and risk of aortic aneurysm. PubMed and Embase databases were searched for studies on adiposity and aortic aneurysm up to 18 March 2026, and random effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). In the UK Biobank, a total of 3,447 incident cases and 183 deaths from aortic aneurysm occurred during 12.3 years follow-up, and in the J-SHC Study, 51 aortic aneurysm deaths occurred during 4 years follow-up. In UK Biobank, HRs (95% CIs) were 1.18 (1.08-1.29), 1.51 (1.36-1.67), 1.45 (1.23-1.70), and 1.56 (1.20-2.02) for a BMI of 25-<30, 30-<35, 35-<40, and ≥ 40 vs. 18.5-<25.0, respectively. Positive associations were also observed for the highest vs. lowest quintile of waist circumference (1.66, 1.48-1.87), waist-to-hip ratio (1.67, 1.48-1.89), hip circumference (1.37, 1.22-1.53), waist-to-height ratio (1.70, 1.51-1.91), fat mass (1.62, 1.44-1.83) and body fat percentage (1.45, 1.28-1.63). In the J-SHC Study, comparing the highest vs. lowest categories the HRs were 1.79 (0.86-4.00, p

Indexed as

AdiposityAortic aneurysmBody mass indexMeta-analysisProspective studiesSystematic reviewWaist circumference

Identifiers

PMID42213332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.