ArticleInfection2026
Site-specific and time-varying Acinetobacter colonization and risk of invasive infection in critically ill patients.
Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeColonization by Acinetobacter baumannii is common among critically ill patients. However, the relative contribution of colonization at different anatomical sites and the impact of dynamic changes in colonization status over time remain incompletely defined.
methodsWe conducted a retrospective cohort study of adult intensive care unit (ICU) patients with at least one surveillance culture positive for carbapenem-resistant Acinetobacter spp. (CRAB) between January 2022 and January 2026. Active surveillance cultures were obtained at ICU admission and weekly thereafter from respiratory, rectal, and skin sites. Progression to invasive CRAB infection (pneumonia and/or bloodstream infection) was assessed using multivariable logistic regression and Cox proportional hazards models with site-specific, time-updated colonization as exposures. Sensitivity analyses excluded infections occurring within 72 h of ICU admission.
resultsAmong 489 colonized ICU patients, 313 (64.0%) progressed to invasive CRAB infection during ICU stay. Respiratory colonization at ICU admission was strongly associated with progression to infection (adjusted OR, 5.46; 95% CI, 3.18-9.37), whereas rectal colonization was not independently associated with risk. In time-updated Cox models, respiratory (adjusted HR, 1.72; 95% CI, 1.35-2.18) and skin colonization (adjusted HR, 1.65; 95% CI, 1.31-2.08) were independently associated with infection risk. Colonization at multiple anatomical sites conferred additional risk.
conclusionsProgression to invasive infection was common and strongly associated with site-specific and time-varying colonization patterns, particularly involving the respiratory tract. Incorporating dynamic, multisite colonization data into risk assessment may improve identification of patients at highest risk for invasive infection and inform targeted infection prevention strategies in the ICU.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.