ArticleAdvances in experimental medicine and biology2026
Synthesis, Characterisation, and Evaluation of the Biological Activities of Medicinal Plants-Based Gold Nanoparticles.
Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gold nanoparticles (AuNPs) were synthesized using extracts from Spirostachys Africana. The AuNPs were characterised using Ultraviolet-Visible spectrophotometry (UV-Vis), X-ray diffraction (XRD), Dynamic light scattering (DLS), Transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). Their antimicrobial activity was tested against World Health Organization (WHO) bacterial priority pathogens. We also assessed their cytotoxicity, anti-inflammatory, and antioxidant activities. The UV-Vis analysis indicated AuNPs formation with surface plasmon resonance (SPR) peaks at 541. The XRD showed face-centred cubic structures with crystalline sizes ranging from 9 to 10 nm. DLS measurements displayed a monodisperse distribution while TEM showed spheroidal AuNPs with sizes of 6-32 nm. The FTIR identified the hydroxyl, carboxyl, and amine groups, involved in reducing and capping of the Au + ions. Antimicrobial assays demonstrated significant antibacterial effects against S. aureus and P. aeruginosa, with MICs of 0.64 and 1.2 mg/mL respectively. Ethanol extracts-conjugated AuNPs exhibited selective cytotoxicity against MCF-7 cancer cells, compared normal cells with an IC₅₀ of 2.67 mg/mL. These AuNPs significantly decreased NO production, indicating anti-inflammatory potential. Methanol-conjugated AuNPs exhibited good antioxidant activity with an IC50 of 38 μg/mL. AuNPs synthesised from S. africana extracts exhibit promising antibacterial activity against AMR pathogens, as well as significant cytotoxic, anti-inflammatory, and antioxidant activities.
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