Evidence map›Paper›PMID 42213327›Full record

ReviewAdvances in experimental medicine and biology2026

The Role of Lactic Acid Bacteria in Colon Cancer Mitigation: Insights into Mechanisms of Action.

Mduduzi P Mokoena, Paul K Chelule, Ivy Rukasha, Xolani H Makhoba, Zukile Mbita, Ademola O Olaniran

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mduduzi P MokoenaDepartment of Pathology, University of Limpopo, Sovenga, South Africa. mduduzi.mokoena@ul.ac.za.
Paul K CheluleDepartment of Public Health, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Ivy RukashaDepartment of Pathology, University of Limpopo, Sovenga, South Africa.
Xolani H MakhobaDepartment of Life and Consumer Sciences, University of South Africa (UNISA), Roodepoort, South Africa.
Zukile MbitaDepartment of Biochemistry Microbiology and Biotechnology, University of Limpopo, Sovenga, South Africa.
Ademola O OlaniranDiscipline of Microbiology, University of KwaZulu-Natal (Westville Campus), Durban, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactic acid bacteria (LAB) have garnered significant attention for their potential role in mitigating cancer through various mechanisms of action, such as immunoregulation. The LAB, primarily from the genera Lactobacillus and Bifidobacterium, contribute to gut health by maintaining microbial balance, enhancing gut barrier function, and producing short-chain fatty acids (SCFAs). Colon cancer and colorectal cancer are some of the leading causes of cancer-related morbidity and mortality worldwide, with their incidence rising in many parts of the world. This review explores the ecology and the contributions of LAB species in maintaining the health of the human gut. We further discuss the specific mechanisms through which gut LAB may reduce the risk of colon cancer and/or colorectal cancer, including the modulation of inflammatory pathways, induction of apoptosis in cancer cells, regulation of gut microbiota composition, metabolic activity, and immunomodulation. By understanding these mechanisms, we could better appreciate the potential of LAB as a preventive strategy against cancer and inform future drug strategies and dietary recommendations.

Indexed as

Colonic NeoplasmsGastrointestinal MicrobiomeLactobacillalesLactobacillusAnimalsBifidobacteriumHumansIntestinal Barrier FunctionProbioticsCancerGut microbiotaImmune systemLactic acid bacteria

Identifiers

PMID42213327

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.