Evidence map›Paper›PMID 42213324›Full record

ArticleAdvances in experimental medicine and biology2026

Prevalence of Drug-Resistant Mycobacterium tuberculosis in Rural Communities of Vhembe District, South Africa.

M S Mashilo, N T Banda, V Mavumengwana, M C Rikhotso, J P Kabue Ngandu, C J Kinnear, N Potgieter, A N Traoré

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Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M S MashiloDepartment of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou, South Africa.
N T BandaDepartment of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou, South Africa.
V MavumengwanaDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
M C RikhotsoDepartment of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou, South Africa.
J P Kabue NganduDepartment of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou, South Africa.
C J KinnearDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
N PotgieterDepartment of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou, South Africa.
A N TraoréDepartment of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant tuberculosis (DR-TB) is still a concern for public health and health security, making TB the world's largest cause of death from a single infectious agent. This Chapter was aimed at evaluating the prevalence of DR-MTB in rural communities of South Africa. A cross-sectional study in rural Vhembe District, South Africa, recruited 175 active TB patients. Data on lifestyle behaviour, socioeconomic, and environmental characteristics were collected via a questionnaire, and samples (blood and sputum) were collected. The U-rapid blood test confirmed HIV status. DNA was extracted from sputum and tested using multiplex real-time PCR assays with Anyplex and Allplex kits to detect Mycobacterium tuberculosis/nontuberculous mycobacteria, as well as DR-TB strains, respectively. The participants' ages ranged from 18 to 82 years (mean = 44 ± 13.0), with the majority being males (57.1%, 100/175) and unemployed (61.1%, 107/175). The co-infections detected include NTM and HIV. The prevalence of DR-MTB was 2.3% (4/175). A 20.6% (36/175) success rate was achieved in treatment outcomes. DR-TB remains low and is effectively managed, with favourable treatment outcomes reflecting effective clinical and public health interventions. However, the high prevalence of emerging NTM and HIV infections may compromise these gains, posing a potential threat to sustained TB control.

Indexed as

Mycobacterium tuberculosisRural PopulationTuberculosis, Multidrug-ResistantAdolescentAdultAgedAged, 80 and overAntitubercular AgentsCoinfectionCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceAntitubercular AgentsDrug-resistant Mycobacterium tuberculosisHIVNontuberculous mycobacteriaRisk factorsRural communitiesTreatment outcome

Identifiers

PMID42213324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.