Evidence map›Paper›PMID 42213318›Full record

ArticleIndian pediatrics2026

The Gut-Urinary Axis in Pediatrics: Fecal Carriage of ESBL-Producing Escherichia coli and Community-Acquired Urinary Tract Infections.

Metin Kaya Gürgöze, Aslıhan Kara, Buket Esen Ağar, Zülal Aşçı Toraman

Abstract read
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In one paragraph

Article in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Metin Kaya GürgözeDepartment of Pediatric Nephrology, Faculty of Medicine, Fırat University, 23119, Elazıg, Turkey.ORCID http://orcid.org/0000-0003-0645-8170
Aslıhan KaraDepartment of Pediatric Nephrology, Faculty of Medicine, Fırat University, 23119, Elazıg, Turkey. aslihanorucoglu@yahoo.com.ORCID http://orcid.org/0000-0003-4410-0444
Buket Esen AğarDepartment of Pediatric Nephrology, Faculty of Medicine, Fırat University, 23119, Elazıg, Turkey.ORCID http://orcid.org/0000-0003-2553-5514
Zülal Aşçı ToramanDepartment of Microbiology, Faculty of Medicine, Fırat University, Elazıg, Turkey.ORCID http://orcid.org/0000-0001-9621-166X

Funding

Firat University Scientific Research Projects Management Unit TF1527
6 · The paper itself

Abstract

objectivesExtended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) is a major driver of multidrug resistance in pediatric urinary tract infections (UTIs). This study investigated fecal ESBL carriage prevalence in children with UTIs and their parents to assess associations with infection phenotypes.

methodsOne-hundred and thirty-three children with E. coli UTIs were categorized into ESBL-positive and non-ESBL groups. Fecal samples were obtained from all children and 190 consenting parents. ESBL production was identified using standard phenotypic methods.

resultsESBL-producing E. coli was detected in 47 (35.4%) urine cultures. Fecal ESBL carriage was significantly more frequent in children with ESBL-positive UTIs (n = 25, 53.2%) compared to non-ESBL group (n = 20, 23.3%) (P < 0.001). Although higher parental ESBL carriage rates were observed in children with ESBL-positive UTIs (11.7% mothers, 20.0% fathers), differences were not statistically significant.

conclusionsFecal carriage of ESBL-producing E. coli is strongly associated with ESBL-positive UTIs, supporting the role of intestinal colonization in infection pathogenesis.

Indexed as

beta-LactamasesCommunity-Acquired InfectionsEscherichia coliEscherichia coli InfectionsFecesUrinary Tract InfectionsCarrier StateChildChild, PreschoolFemaleHumansInfantMalePrevalencebeta-LactamasesChildrenEscherichia coliExtended-spectrum beta-lactamasesFecal carriageUrinary tract infection

Identifiers

PMID42213318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.