ArticleDiscover nano2026
Synthesis and characterization of bifunctional nanoprobes for targeted photodynamic therapy in breast cancer treatment.
Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
The overexpressed epidermal growth factor receptor (EGFR) in lung, breast, and colorectal cancers is associated with an increased risk of mortality. Therefore, targeted photodynamic therapy (PDT) has emerged as an alternative for cancer treatment. To enable EGFR-directed PDT, this study reports the synthesis of a bifunctional nanoprobe (NP-BF) based on gold nanoparticles (AuNPs) functionalized with the monoclonal antibody cetuximab (CX) and the photosensitizer chlorin e6 (Ce6) using carbodiimide chemistry. The resulting NP-BF showed spectroscopic evidence of successful conjugation through amide bond formation, preservation of the structural features of cetuximab, and retention of the photophysical properties of Ce6 after functionalization. In addition, the nanosystem remained colloidally stable, exhibiting a zeta potential of - 40.7 mV and an increase in hydrodynamic diameter of approximately 9 nm, consistent with antibody incorporation. A cellular uptake assay using the MDA-MB-468 cell line revealed internalization with maximum uptake in 60 min, corresponding to approximately 1.32 × 10
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