Evidence map›Paper›PMID 42213267›Full record

ArticleAging clinical and experimental research2026

Methodological concerns in the association between gut microbiota and sarcopenia: from cross‑sectional associations to statistical fragility.

Sharipova Gulnihol, Nurullaev Abdukhamid, Turakulov Rustam, Ulmasov Firdavs, Arman Abroumand Gholami

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharipova GulniholDepartment of Hygiene, No 2 of the Bukhara state medical institute named after Abu Ali Ibn Sino, Bukhara, Uzbekistan.
Nurullaev AbdukhamidFaculty of Physical Culture Bukhara State Pedagogical Institute, Piridastgir street, 2nd house, Bukhara, Uzbekistan.
Turakulov RustamDepartment of internal medicine in family medicine, Tashkent State Medical University, Tashkent, Uzbekistan.
Ulmasov FirdavsDepartment of Oncology, Samarkand State Medical University, Samarkand, Uzbekistan.
Arman Abroumand GholamiNervous System Stem Cell Research Center, Semnan University of Medical Sciences, Semnan, Iran. aroma3162@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This commentary critically appraises the cross‑sectional study by Nasrollahizadeh et al. on gut microbiota and sarcopenia in Iranian older adults. Key limitations include; after FDR correction for twelve bacterial genera, no significant differences remained between groups; Akkermansia lost significance in sensitivity analyses; Lactobacillus showed a confidence interval including 1.00; four primer pairs lacked validation with no MIQE‑compliant efficiency data; the cross‑sectional design precludes causal inference; and no sample size justification was reported. The study offers valuable hypothesis‑generating data, but evidence remains preliminary. Future longitudinal studies with metagenomic approaches are essential.

Indexed as

Gastrointestinal MicrobiomeSarcopeniaAgedCross-Sectional StudiesHumansIranCross-sectional studyFDRGut microbiotaMIQE guidelinesSarcopenia

Identifiers

PMID42213267
PMCPMC13221414

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.