Evidence map›Paper›PMID 42213246›Full record

ArticleMolecular neurobiology2026

Microglia-Mediated Dysfunction of PKCγ Interneurons Underlies the Mechanical Hypersensitivity in Autism.

Yiwei Yao, Xinyang Gu, Wenqing Huang, Chutian Huang, Bei Li, Junmei Zhou, Qian Li

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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiwei YaoDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China.
Xinyang GuDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China.
Wenqing HuangDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China.
Chutian HuangDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China.
Bei LiDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China.
Junmei ZhouDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China. zhoujm@shchildren.com.cn.
Qian LiDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, 355 Luding Road, Putuo District, Shanghai, 200062, China. liq2024@shchildren.com.cn.

Funding

National Natural Science Funds of China 82171164; 81500946
6 · The paper itself

Abstract

Children with autism spectrum disorder (ASD) often exhibit heightened sensitivity to innocuous mechanical stimuli, such as gentle touch or friction from clothing. However, the neural mechanisms underlying these ASD-associated tactile deficits remain unclear. In the present study, we found that the maternal immune activation (MIA) mouse model of ASD displayed marked mechanical hypersensitivity. Following innocuous mechanical stimulation to the hind paw, protein kinase C gamma (PKCγ) excitatory interneurons were activated in the spinal dorsal horn. Importantly, the activation of PKCγ interneurons contributed to mechanical hypersensitivity in MIA mice. As the density of VGAT

Indexed as

Autistic DisorderHyperalgesiaInterneuronsMicrogliaProtein Kinase CAnimalsDisease Models, AnimalFemaleMaleMice, Inbred C57BLPhagocytosisSpinal CordSpinal Cord Dorsal HornSynapsesVesicular Inhibitory Amino Acid Transport ProteinsProtein Kinase Cprotein kinase C gammaVesicular Inhibitory Amino Acid Transport ProteinsAutism spectrum disorderMaternal immune activationMechanical hypersensitivityMicrogliaPKCγ interneurons

Identifiers

PMID42213246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.