Evidence map›Paper›PMID 42213234›Full record

ArticleHead and neck pathology2026

Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.

Ricardo Anderson de Oliveira Vasconcelos, Isaac Santos Araújo, Luiz Miguel Ferreira, João Paulo Gonçalves de Paiva, Igor Lima Fernandes, Lucas Faria Abrahao-Machado, Claudia Haydee Sarai Caro-Sánchez, Ana María Cano-Valdez, Adalberto Mosqueda-Taylor, Ciro Dantas Soares

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Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Ricardo Anderson de Oliveira VasconcelosOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Avenida Limeira 901, Areião, Piracicaba, São Paulo, 13414-900, Brazil.ORCID http://orcid.org/0000-0003-2720-5826
Isaac Santos AraújoOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Avenida Limeira 901, Areião, Piracicaba, São Paulo, 13414-900, Brazil.ORCID http://orcid.org/0000-0003-0295-7925
Luiz Miguel FerreiraOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Avenida Limeira 901, Areião, Piracicaba, São Paulo, 13414-900, Brazil.ORCID http://orcid.org/0000-0003-2053-8097
João Paulo Gonçalves de PaivaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Avenida Limeira 901, Areião, Piracicaba, São Paulo, 13414-900, Brazil.ORCID http://orcid.org/0000-0002-0079-2373
Igor Lima FernandesBacchi Pathology Laboratory, Botucatu, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0377-0441
Lucas Faria Abrahao-MachadoBacchi Pathology Laboratory, Botucatu, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-3790-4479
Claudia Haydee Sarai Caro-SánchezNational Cancer Institute, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-3792-6758
Ana María Cano-ValdezNational Cancer Institute, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9459-7351
Adalberto Mosqueda-TaylorHealth Care Department, Universidad Autónoma Metropolitana, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-8956-6016
Ciro Dantas SoaresOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Avenida Limeira 901, Areião, Piracicaba, São Paulo, 13414-900, Brazil. cirods@unicamp.br.ORCID http://orcid.org/0000-0002-6861-6640

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWarthin-like mucoepidermoid carcinoma (WL-MEC) is a low-grade variant of mucoepidermoid carcinoma (MEC), characterized by a multicystic growth pattern and dense lymphoid stroma, histologically mimicking Warthin tumor (WT). Few cases have been reported, limiting understanding of this variant. We aimed to provide a comprehensive clinical, histopathologic, and molecular analysis of new WL-MEC cases. METHODS AND

resultsFourteen WL-MEC cases from Brazil, Guatemala, and Mexico were analyzed. Clinicopathologic features (patient demographics, tumor location, AFIP grading, follow-up, recurrence), histological characteristics (architectural patterns, inflammatory infiltrate, epithelial components, invasion), and immunohistochemical profiles (CK5/6, p63, p40, CK7, CK14, Ki67, HER2) were assessed. MAML2 generearrangements and HER2 amplification were evaluated by fluorescence in situ hybridization (FISH). All 14 cases showed MAML2 rearrangement (100%), confirming the diagnosis, while HER2 amplification was absent in all 9 cases tested.

conclusionsThis study provides new insights into the clinicopathological and molecular features of WL-MEC, confirming its typical presentation (parotid gland, middle-aged females), low-grade behavior, and favorable prognosis after surgical excision. Detection of MAML2 rearrangement is a valuable diagnostic tool for distinguishing WL-MEC from WT.

Indexed as

AdenolymphomaCarcinoma, MucoepidermoidParotid GlandSalivary Gland NeoplasmsTrans-ActivatorsAdultAgedDiagnosis, DifferentialFemaleGene RearrangementHispanic or LatinoHumansLatin AmericaMaleMiddle AgedSouth American PeopleMAML2 protein, humanTrans-ActivatorsMucoepidermoid carcinomaSalivary glandWarthin-like mucoepidermoid carcinomaWarthin tumor

Identifiers

PMID42213234
PMCPMC13221507

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.