ArticleJournal of neural transmission (Vienna, Austria : 1996)2026
Parkinson's disease-subjective cognitive decline and health-related quality of life.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
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41 authors.
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Abstract
backgroundParkinson's disease-subjective cognitive decline (PD-SCD) is defined by subjective cognitive complaints (SCC) in the absence of objective cognitive impairment and has been associated with an increased risk of future cognitive decline. However, its impact on health-related quality of life (HRQoL) remains unclear. This is particularly relevant in early PD, when patients often maintain high levels of social-occupational functioning and subtle cognitive concerns may interfere with daily life. This study aimed to explore the association between SCC and HRQoL in cognitively unimpaired PD patients (PD-SCD).
methodsCross-sectional data from the COPPADIS cohort were analyzed. Patients with normal cognition according to PD-MCI level I criteria (Parkinson's Disease-Cognitive Rating Scale > 81) were included. HRQoL was assessed using the 39-item Parkinson's Disease Questionnaire (PDQ-39). SCC were defined as a Non-Motor Symptoms Scale (NMSS) domain 5 ≥ 1.
resultsA total of 497 patients with median age 62 years, disease duration 4 years, and 61% of PD-SCD were included. HRQoL was significantly worse in PD-SCD patients across all PDQ-39 domains. In adjusted linear regression models, PD-SCD was independently associated with higher PDQ-39 total score as well as with worse scores in activities of daily living, social support, cognition, and communication domains.
conclusionsPD-SCD is independently associated with poorer HRQoL across multiple domains. These findings highlight the clinical relevance of SCC within a patient-centered approach to PD management.
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