Evidence map›Paper›PMID 42213144›Full record

ArticleClinical oral investigations2026

Longitudinal biomarker profiles during experimental gingivitis: a predictor of susceptibility.

Ren Jie Jacob Chew, Susan M Bissett, Katrin M Jaedicke, Rachel van der Merwe, Clement Wei Ming Lai, Charlene Enhui Goh, Dale Athey, John J Taylor, Philip M Preshaw

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Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ren Jie Jacob ChewFaculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore, 119085, Singapore. dencrjj@nus.edu.sg.
Susan M BissettSchool of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.
Katrin M JaedickeFaculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, UK.
Rachel van der MerweSchool of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.
Clement Wei Ming LaiFaculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore, 119085, Singapore.
Charlene Enhui GohFaculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore, 119085, Singapore.
Dale AtheySalvivo Limited, Newcastle upon Tyne, UK.
John J TaylorSchool of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.
Philip M PreshawSchool of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore longitudinal changes and prognostic applications of salivary IL-1β and MMP-8 in determining gingivitis susceptibility. MATERIALS AND

methodsTwenty-seven systemically healthy adults with periodontal health or gingivitis were enrolled. Participants underwent a 3-week hygiene phase (V

resultsTen and 17 participants had high and low gingivitis susceptibility, respectively. While there were no differences in the biomarker profiles during the experimental gingivitis phase, high susceptibility individuals were associated with a profile of elevated IL-1β and MMP-8 during the hygienic phase (p = 0.024) and increased salivary IL-1β at V

conclusionSalivary biomarker profiles during the hygienic phase may offer insights into an individual's susceptibility to gingivitis. Additional research will be needed to validate these findings for the general population, translating these biomarkers into prognostic tools that enable personalised periodontal care. CLINICAL RELEVANCE: Salivary biomarkers may provide additional prognostic insight into gingivitis susceptibility.

Indexed as

GingivitisInterleukin-1betaMatrix Metalloproteinase 8SalivaAdultBiomarkersDisease SusceptibilityFemaleHumansLongitudinal StudiesMaleOral HygienePeriodontal IndexPrognosisBiomarkersInterleukin-1betaMatrix Metalloproteinase 8BiomarkersExperimental gingivitisGingivitisOral hygieneSaliva

Identifiers

PMID42213144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.