Evidence map›Paper›PMID 42213136›Full record

ArticleAnnals of hematology2026

CD33 expression combined with D15-MRD positivity identifies poor prognosis in children with ETV6::RUNX1-positive ALL.

Xueling Zheng, Yuxi Luo, Ruidong Zhang, Xiaohang Liu, Pengli Huang, Chao Gao, Hui Chen, Jia Fan, Wei Lin, Jiaole Yu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xueling ZhengHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yuxi LuoHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Ruidong ZhangHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Xiaohang LiuCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Pengli HuangHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Chao GaoDepartment of Clinical Laboratory Center, National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Hui ChenDepartment of Clinical Laboratory Center, National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Jia FanHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Wei LinHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Jiaole YuHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yuanyuan ZhangHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Peijing QiHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Ying WuHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Xiaoxi ZhaoDepartment of Clinical Laboratory Center, National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Jun LiDepartment of Clinical Laboratory Center, National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Xiaoxia PengCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Tianyou WangHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. wangtianyou@bch.com.cn.
Huyong ZhengHematology Center, National Key Discipline of Pediatric Hematology, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. zhenghuyong@bch.com.cn.

Funding

Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special "Yang Fan" Grant ZLRK202328
6 · The paper itself

Abstract

While ETV6::RUNX1-positive acute lymphoblastic leukemia (ALL) is generally associated with favorable outcomes, a subset of patients experience relapse despite receiving standard therapy, underscoring the need for early biomarkers to identify high-risk subgroups. In this retrospective study of 345 consecutive pediatric patients with ETV6::RUNX1-positive ALL treated in accordance with the protocol of the Chinese Children's Leukemia Group (CCLG-ALL 2008), CD33 expression (CD33

Indexed as

Core Binding Factor Alpha 2 SubunitOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins c-etsRepressor ProteinsSialic Acid Binding Ig-like Lectin 3AdolescentBiomarkers, TumorChildChild, PreschoolDisease-Free SurvivalETS Translocation Variant 6 ProteinFemaleHumansInfantMaleBiomarkers, TumorCD33 protein, humanCore Binding Factor Alpha 2 SubunitETS Translocation Variant 6 ProteinOncogene Proteins, FusionProto-Oncogene Proteins c-etsRepressor ProteinsRUNX1 protein, humanSialic Acid Binding Ig-like Lectin 3Acute lymphoblastic leukemiaCD33ETV6:: RUNX1PediatricPrognosis

Identifiers

PMID42213136
PMCPMC13408124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.