ArticleJACC. Case reports2026
Oxygen-Refractory Platypnea-Orthodeoxia Syndrome Requiring Urgent Surgical Closure: A Dynamic Assessment.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Platypnea-Orthodeoxia Syndrome: A Distinct Entity or a Phenotype of Dynamic Shunting?JACC. Case reports · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatypnea-orthodeoxia syndrome (POS) causes posture-dependent hypoxemia due to right-to-left shunt, and it may be underestimated by routine evaluation. CASE SUMMARY: An 84-year-old woman developed oxygen-refractory, posture-dependent hypoxemia during facial cellulitis and after contracting COVID-19. Transesophageal echocardiography identified a large patent foramen ovale with dynamic right-to-left shunt. Provocative assessment using invasive oximetry under a semi-sitting position and abdominal compression demonstrated a decrease in pulmonary-to-systemic flow ratio from 0.66 to 0.59. Because an intrahepatic inferior vena cava with focal narrowing rendered transcatheter closure infeasible, urgent surgical patent foramen ovale closure was performed, resulting in rapid improvement in oxygenation. DISCUSSION: Dynamic, flow-driven POS may be underestimated by routine evaluation, and provocative assessment is essential in guiding urgent surgical closure when transcatheter intervention is infeasible. TAKE-HOME MESSAGES: Provocative transesophageal echocardiography and invasive oximetry can identify POS when routine evaluation is inconclusive. Surgical closure should be considered when transcatheter closure is anatomically infeasible.
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