Evidence map›Paper›PMID 42212830›Full record

ArticlemBio2026

A novel host-targeted inhibitor of clathrin-mediated endocytosis limits spring viremia of carp virus infection.

Lei Liu, Yan Zhou, Huan Wang, Yang Hu, Jiong Chen

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei Liu *State Key Laboratory for Quality and Safety of Agro-Products, Ningbo University, Ningbo, China.ORCID 0000-0002-2227-8789
Yan Zhou *State Key Laboratory for Quality and Safety of Agro-Products, Ningbo University, Ningbo, China.
Huan WangState Key Laboratory for Quality and Safety of Agro-Products, Ningbo University, Ningbo, China.
Yang HuState Key Laboratory for Quality and Safety of Agro-Products, Ningbo University, Ningbo, China.
Jiong ChenState Key Laboratory for Quality and Safety of Agro-Products, Ningbo University, Ningbo, China.ORCID 0000-0001-9389-520X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spring viremia of carp virus (SVCV), an aquatic rhabdovirus, causes lethal disease and major economic losses in carp aquaculture, yet no licensed antivirals are available. In this study, we identify the plant-derived diterpenoid quinone cryptotanshinone (CPT) as a potent inhibitor of SVCV that acts by inhibiting clathrin-mediated endocytosis (CME) and attenuating early mitochondrial apoptosis. CPT was well tolerated by epithelioma papulosum cyprinid cells (50% cytotoxic concentration [CC

Indexed as

Antiviral AgentsClathrinEndocytosisFish DiseasesRhabdoviridaeRhabdoviridae InfectionsViremiaAnimalsApoptosisCarpsCell LineVirus InternalizationVirus ReplicationAntiviral AgentsClathrinactive monomerantiviralaquatic rhabdovirusclathrinendocytosisinternalization

Identifiers

PMID42212830
PMCPMC13344028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.