ReviewmSphere2026
Hidden battles: dissecting host-fungal interactions and immune heterogeneity in infection outcomes.
Review in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal infections remain a major global human health problem, responsible for billions of infections and millions of deaths each year. Dissecting the immune mechanisms that protect us against these infections is an important step toward developing alternative therapies for patients at risk for fungal diseases, who are typically immunocompromised. Understanding antifungal immune responses is complicated by heterogeneity within host cell populations, as well as in-host adaptation strategies employed by fungi, which may also drive multiple distinct populations during infection. In this article, I discuss our recent discoveries and that of the medical mycology field, which has used creative and interdisciplinary approaches to better define the multiple layers of complexity that influence host-fungal interactions and infection outcomes. Finally, I describe examples where fundamental discovery has translated into new treatment approaches for patients and may represent revolutionary changes for our growing field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.