Evidence map›Paper›PMID 42212792›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026

Adenotonsillectomy is associated with increased risk and disease activity in pediatric-onset multiple sclerosis.

Gina Chang, Zahra Nasr, Vinicius Andreoli Schoeps, Akash Virupakshaiah, Scott S Zamvil, Carson E Moseley, Joseph J Sabatino, Janet Chong, Jennifer S Graves, Michael Waltz and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Gina ChangUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0572-4847
Zahra NasrUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4712-4679
Vinicius Andreoli SchoepsHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-8875-0567
Akash VirupakshaiahUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2624-9974
Scott S ZamvilUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Carson E MoseleyUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8859-3792
Joseph J SabatinoUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Janet ChongUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Jennifer S GravesUniversity of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-1539-1940
Michael WaltzUniversity of Utah School of Medicine, Salt Lake City, UT, USA.
Moses RodriguezMayo Clinic, Rochester, MN, USA.ORCID 0000-0001-6328-6497
Jan-Mendelt TillemaMayo Clinic, Rochester, MN, USA.
Tanuja ChitnisHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-9897-4422
Mary RenselCleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-9613-8394
Aaron W AbramsCleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-4607-5740
Lauren KruppNew York University Langone Health, New York City, NY, USA.ORCID 0000-0001-7003-807X
Amy T WaldmanChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Soe MarWashington University in St. Louis, St. Louis, MO, USA.
Teri SchreinerUniversity of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-3816-812X
John RoseUniversity of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0003-2382-5921
T Charles CasperUniversity of Utah School of Medicine, Salt Lake City, UT, USA.
Emmanuelle WaubantUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5188-0157

Funding

Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
NINDS NIH HHS R01 NS071463
6 · The paper itself

Abstract

backgroundEpstein-Barr virus (EBV) is a key environmental risk factor for multiple sclerosis (MS), and tonsils and adenoids serve as a primary viral reservoir. This study investigates the potential role of adenotonsillectomy in pediatric-onset multiple sclerosis (POMS) risk and relapse rate.

objectivesPOMS participants and controls were recruited from 16 pediatric MS clinics between 1 November 2011 and 1 July 2017. Clinical and demographic information, including history of adenotonsillectomy, EBV serostatus, and

resultsThe case-control analysis included 359 POMS participants and 560 pediatric controls. Individuals with a history of adenotonsillectomy had a 63% increased odds of MS (adjusted odds ratio (OR) = 1.63, 95% confidence interval (CI) = 1.01-2.64,

conclusionsPrior adenotonsillectomy was associated with increased risk of MS and greater relapse rate in pediatric patients, suggesting a potential interplay between EBV, immune regulation, and MS pathogenesis.

Indexed as

AdenoidectomyEpstein-Barr Virus InfectionsMultiple SclerosisTonsillectomyAdolescentCase-Control StudiesChildFemaleHerpesvirus 4, HumanHumansMaleRecurrenceRisk Factorsadenoidectomyannualized relapse ratePediatric-onset multiple sclerosisrisk factorstonsillectomy

Identifiers

PMID42212792
PMCPMC13225604

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.