Evidence map›Paper›PMID 42212739›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Mitochondria-Targeted Photodynamic Agents Drive Robust Pyroptosis by Caspase-3/GSDME Activation and Cardiolipin Externalization.

Dongsheng Zhang, Xueli Zhang, Mengyuan Huang, Li-Ya Niu, Kun-Xu Teng, Qing-Zheng Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongsheng ZhangSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, People's Republic of China.
Xueli ZhangSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, People's Republic of China.
Mengyuan HuangSchool of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, People's Republic of China.
Li-Ya NiuKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, People's Republic of China.
Kun-Xu TengKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, People's Republic of China.ORCID 0000-0002-9391-9889
Qing-Zheng YangKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, People's Republic of China.ORCID 0000-0002-9131-4907

Funding

Beijing Natural Science Foundation 2262013Beijing Natural Science Foundation 2262014National Natural Science Foundation of China 22231001National Natural Science Foundation of China 22301017National Natural Science Foundation of China 22301067National Natural Science Foundation of China 22477009National Natural Science Foundation of China 22595403Postdoctoral Fellowship Program of CPSF GZC20230729
6 · The paper itself

Abstract

Photodynamic therapy (PDT)-induced pyroptosis has attracted considerable interest as a strategy for cancer therapy, yet rational design of photosensitizers (PSs) that efficiently elicit pyroptosis remains underdeveloped. Herein, we report mitochondria-targeted supramolecular PSs that simultaneously activate the caspase-3/gasdermin E (GSDME) signal pathway and promote cardiolipin (CL) externalization to drive robust PDT-induced pyroptosis. A series of BODIPY-based supramolecular PSs, containing quaternary-ammonium moieties and N-containing aromatic heterocyclic substituents, were rationally designed for mitochondrial accumulation and ROS generation. Upon light irradiation, these PSs elicit pronounced pyroptosis. Transmission electron microscopy and Calcein AM/Co

Indexed as

Antineoplastic AgentsCardiolipinsCaspase 3MitochondriaPhotochemotherapyPhotosensitizing AgentsPyroptosisAnimalsGasderminsHumansMiceReactive Oxygen SpeciesAntineoplastic AgentsCardiolipinsCaspase 3GasderminsPhotosensitizing AgentsReactive Oxygen Speciesphotodynamic therapyphotosensitizerpyroptosisreactive oxygen speciesself‐assembly

Identifiers

PMID42212739
PMCPMC13411377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.