Evidence map›Paper›PMID 42212729›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Non-Covalent [4Fe-4S]/[2Fe] Interface in HydF Guides [FeFe]-Hydrogenase Maturation.

Giorgio Caserta, Princess R Cabotaje, Armel T Waffo, Deepak Prajapat, Ilya Sergueev, Stefan Frielingsdorf, Gustav Berggren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giorgio CasertaInstitut für Chemie, Technische Universität Berlin, Berlin, Germany.ORCID 0000-0003-0986-3059
Princess R CabotajeDepartment of Chemistry─Ångström Laboratory, Molecular Biomimetics, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-0500-5981
Armel T WaffoInstitut für Chemie, Technische Universität Berlin, Berlin, Germany.
Deepak PrajapatDeutsches Elektronen-Synchrotron, Hamburg, Germany.ORCID 0000-0002-6269-8382
Ilya SergueevDeutsches Elektronen-Synchrotron, Hamburg, Germany.ORCID 0000-0002-7614-2238
Stefan FrielingsdorfInstitut für Chemie, Technische Universität Berlin, Berlin, Germany.ORCID 0000-0002-4141-7836
Gustav BerggrenDepartment of Chemistry─Ångström Laboratory, Molecular Biomimetics, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-6717-6612

Funding

Deutsche Forschungsgemeinschaft EXC2008-390540038Swedish Research Council 2021-04471
6 · The paper itself

Abstract

Maturation of [FeFe]-hydrogenase depends on the HydF maturase, a [4Fe-4S]-containing scaffold protein that assembles and delivers the organometallic [2Fe] subsite of the H-cluster. Despite extensive research, the function of the HydF [4Fe-4S] cluster and its interaction with the [2Fe] cofactor remains unresolved, with conflicting evidence regarding cyanide linkage isomerism and the functional role of the cubane. Using

Indexed as

HydrogenaseIron-Sulfur ProteinsModels, MolecularHydrogenaseiron hydrogenaseIron-Sulfur Proteinsbiosynthesishydrogenaseiron‐sulfur clustersmetalloenzymesnrvs

Identifiers

PMID42212729
PMCPMC13360658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.