ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
Mechanochemical Amidation Mediated by 1,1'-Oxalyldiimidazole for the Synthesis of Agrochemicals.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The synthesis of amide moieties, essential components in both pharmaceuticals and agrochemicals, traditionally involves environmentally hazardous and polluting processes. This study presents a novel mechanochemical method to form amide bond using 1,1'-oxalyl diimidazole (ODI) as activating agent, and evaluates its applicability in synthesizing agrochemicals such as Mepronil, Flutolanil, and Fluxapyroxad at gram-scale. The mechanochemical kinetics underlying the synthesis of the three mentioned compounds was also investigated. The new method was compared with the similar 1,1'-carbonyl diimidazole (CDI)-mediated mechanochemical amidation previously reported. Results demonstrate that ODI-mediated synthesis outperforms in the case of deactivated acids. Energetic considerations and technical process parameters are also discussed to provide quantitative technology assessment. A comprehensive analysis by green chemistry metrics with CHEM21 and DOZN
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