Evidence map›Paper›PMID 42212555›Full record

ReviewMediators of inflammation2026

Targeting IL-17 Presents a Promising Strategy for Treating Diseases Related to the Dysregulation of Lipid Homeostasis.

Chen Zhang, Yu-Yue Xue, Dian-Qun Ren, Jia-Feng Zhu, Xin Jin, Jie Liu

Abstract readReview
In one paragraph

Review in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen ZhangJiaxing Graduate Joint Training Base, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China, zcmu.edu.cn.ORCID https://orcid.org/0009-0000-9023-1184
Yu-Yue XueJiaxing Graduate Joint Training Base, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China, zcmu.edu.cn.
Dian-Qun RenJiaxing Hospital of Traditional Chinese Medicine, Jiaxing, 314000, Zhejiang, China.
Jia-Feng ZhuJiaxing Hospital of Traditional Chinese Medicine, Jiaxing, 314000, Zhejiang, China.
Xin JinJiaxing Graduate Joint Training Base, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China, zcmu.edu.cn.
Jie LiuJiaxing Hospital of Traditional Chinese Medicine, Jiaxing, 314000, Zhejiang, China.ORCID https://orcid.org/0009-0002-0687-481X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipids are fundamental constituents of cell membranes and play a crucial role in signaling pathways that regulate a wide array of cellular functions. Consequently, the dysregulation of lipid homeostasis is recognized as a significant contributor to metabolic diseases. Given the limitations of current strategies for regulating lipid metabolism, it is essential to explore innovative approaches to modulate lipid homeostasis to effectively address diseases associated with its dysregulation. Inflammation plays a critical role in the regulation of lipid metabolism, acting through various pathways and mechanisms that influence both lipid synthesis and degradation. The involvement of Interleukin-17 (IL-17) in inflammatory responses is particularly noteworthy, as recent studies have highlighted its impact on lipid metabolism, particularly in the context of obesity and metabolic disorders. This review critically examines the IL-17 signaling pathway, elucidates the mechanisms by which IL-17 affects lipid metabolism, and explores the therapeutic potential of targeting IL-17 in the treatment of disorders related to lipid homeostasis. This review underscores the promise of targeting IL-17 signaling pathways as a therapeutic strategy for addressing the dysregulation in lipid homeostasis.

Indexed as

Interleukin-17Lipid MetabolismAnimalsHomeostasisHumansInflammationObesitySignal TransductionInterleukin-17atherosclerosischolesterol homeostasisfatty acid synthesisIL-17inflammationlipid metabolismmalignancynonalcoholic fatty liver diseaseobesitySTAT3 signaling pathway

Identifiers

PMID42212555
PMCPMC13239054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.