Evidence map›Paper›PMID 42212535›Full record

ArticleJournal of the American Chemical Society2026

Optimized Biomimetic Syntheses of Discorhabdin B and Aleutianamine Drives a Deeper Exploration of Their Anticancer Potential.

Nicholas L Magann, Griffin L Barnes, Ryan Schioldager, Fabian M Hörmann, Rubén Muñoz, Haiyong Han, Daniel Von Hoff, Christopher D Vanderwal

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas L MagannDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697, United States.
Griffin L BarnesDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697, United States.
Ryan SchioldagerDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697, United States.
Fabian M HörmannDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697, United States.
Rubén MuñozClinical Genomics and Therapeutics Division, Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, Arizona 85004, United States.
Haiyong HanClinical Genomics and Therapeutics Division, Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, Arizona 85004, United States.
Daniel Von HoffClinical Genomics and Therapeutics Division, Translational Genomics Research Institute (TGen), Part of City of Hope, Phoenix, Arizona 85004, United States.
Christopher D VanderwalDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697, United States.ORCID 0000-0001-7218-4521

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Chemical Synthesis of Bioactive DiterpenoidsR35GM145252 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christopher D Vanderwal · 2022 to 2026
$2.1M
NCI NIH HHS P30 CA062203NIGMS NIH HHS R35 GM145252
6 · The paper itself

Abstract

The structurally novel marine alkaloid aleutianamine was reported to have potent and selective activity against the PANC-1 pancreatic cancer cell line, inspiring the development of three exceptional recent syntheses. Our efforts toward a bioinspired, "Kita-style" synthesis met with challenges until we adopted the presumably biomimetic rearrangement of

Indexed as

Antineoplastic AgentsBiomimetic MaterialsPyrroloiminoquinonesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureAntineoplastic AgentsPyrroloiminoquinones

Identifiers

PMID42212535
PMCPMC13256245

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.