Evidence map›Paper›PMID 42212315›Full record

ArticleInternational journal of biological sciences2026

SIRT3 activation by oroxylin A phosphate diethyl ester triggers mitochondrial dysfunction and apoptosis in non-small cell lung cancer.

Chiang-Wen Lee, Yu-Feng Lin, Kuan-Han Lee, Ying-Sui Sun, Tsung-Ming Chang, Miao-Ching Chi, Zih-Chan Lin, Ayaho Yamamoto, Kuo-Ti Peng, Ju-Fang Liu

Abstract read
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In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiang-Wen LeeDepartment of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.
Yu-Feng LinDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.
Kuan-Han LeeSchool of Pharmacy, Tzu Chi University, Hualien 970374, Taiwan.
Ying-Sui SunSchool of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Tsung-Ming ChangSchool of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Miao-Ching ChiDepartment of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.
Zih-Chan LinChronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.
Ayaho YamamotoChild Health Research Centre, The University of Queensland, South Brisbane, Queensland 4101, Australia.
Kuo-Ti PengDepartment of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan.
Ju-Fang LiuSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer remains the leading cause of cancer mortality worldwide, and outcomes for advanced non-small cell lung cancer (NSCLC) are limited by resistance and toxicity. Sirtuin 3 (SIRT3), a mitochondrial NAD

Indexed as

ApoptosisCarcinoma, Non-Small-Cell LungLung NeoplasmsMitochondriaSirtuin 3AnimalsCell Line, TumorCell ProliferationHumansMiceMice, NudeSIRT3 protein, humanSirtuin 3lung cancermitochondrial dysfunctionmitochondrial fissionOA-OEtSIRT3

Identifiers

PMID42212315
PMCPMC13215253

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.