ArticleInternational journal of women's health2026
Synergistic Efficacy of Calcitriol Combined with Denosumab versus Calcitriol Alone in Postmenopausal Osteoporosis: A Retrospective Cohort Study.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the efficacy and safety of calcitriol combined with denosumab versus calcitriol alone in postmenopausal osteoporosis (PMO). Methods: In this retrospective cohort study, 306 postmenopausal women with PMO were divided into two groups: an intervention group (n = 144) receiving calcitriol, denosumab, and calcium/vitamin D3, and a control group (n = 162) receiving calcitriol and calcium/vitamin D3 only, over 12 months. Outcomes included bone mineral density (BMD), bone turnover markers, calcium-phosphate homeostasis, patient-reported outcomes (VAS, ODI, BI), and adverse events. Results: The intervention cohort demonstrated more pronounced enhancements in BMD measured at the lumbar spine, femoral neck, and total hip (all Conclusion: Calcitriol combined with denosumab synergistically enhances BMD, suppresses bone turnover, improves functional outcomes, and maintains a favorable safety profile in PMO, representing a promising therapeutic strategy.
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