Evidence map›Paper›PMID 42212214›Full record

ArticleIranian journal of basic medical sciences2026

Norepinephrine promotes the proliferation, migration, and phenotypic transformation of renal artery vascular smooth muscle cells via ROCK1.

Sixuan Chen, Lina Wang, Lu Wang, Hui Li, Junyao Lu, Yaxin He, Yihong Zhang, Yuanyuan Guo, Mingyu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sixuan ChenDepartment of Cardiology,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Lina WangDepartment of Geriatrics,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Lu WangDepartment of Geriatrics,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Hui LiDepartment of Geriatrics,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Junyao LuThe Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Yaxin HeDepartment of Geriatrics,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Yihong ZhangDepartment of endocrinology, Heilongjiang Province Hospital, Harbin 150088, China.
Yuanyuan GuoDepartment of Cardiology,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.
Mingyu LiuDepartment of Cardiology,The First Affiliated Hospital, Harbin Medical University, Harbin 150088, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study investigated the role of norepinephrine (NE) and ROCK1 in regulating renal artery vascular smooth muscle cells (rVSMCs). Materials and Methods: rVSMCs were treated with NE, and ROCK1 expression was assessed. Cell proliferation, migration, and phenotypic switching were evaluated using EdU incorporation and wound-healing assays. ROCK1 was silenced by siRNA. Mitochondrial membrane potential and morphology were analyzed to determine NE-induced mitochondrial alterations. Results: NE significantly up-regulated ROCK1 expression in rVSMCs. It promoted proliferation, migration, and phenotypic switching, as indicated by increased expression of proliferative and migratory markers, whereas ROCK1 silencing attenuated these effects. NE also reduced mitochondrial membrane potential and induced mitochondrial fission, suggesting an additional mechanism contributing to vascular remodeling. Conclusion: NE promotes rVSMCs proliferation, migration, and phenotypic switching through ROCK1 activation and alters mitochondrial dynamics. These findings identify the NE-ROCK1 axis as a critical mediator of vascular remodeling in hypertensive nephropathy and suggest it may serve as a promising therapeutic target.

Indexed as

Hypertensive nephropathy Mitochondrial fission NorepinephrineRho-associated kinase Vascular smooth muscle- cells

Identifiers

PMID42212214
PMCPMC13213450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.