ReviewFrontiers in immunology2026
The role of the complement system in gastrointestinal-related diseases.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Protective immunity againstmSphere · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system bridges innate and adaptive immunity, orchestrating immune surveillance and maintaining tissue homeostasis. This review summarizes the role of the complement system in gastrointestinal-related diseases, including its function in innate immunity, impact on adaptive immunity, and regulatory role under physiological and pathological conditions in the gut. The activation pathways, regulatory mechanisms, and interactions of the complement system with the gut microbiome are crucial for maintaining intestinal homeostasis. Genetic deficiencies or excessive activation of the complement system are closely associated with the development of various intestinal diseases, including infections, inflammatory bowel disease (IBD), and tumors. This review also explores the role of the complement system in the tumor microenvironment (TME) of the gut and its potential as a therapeutic target. By deepening our understanding of the mechanisms by which the complement system operates in gastrointestinal diseases, we can provide a theoretical foundation for the development of novel treatment strategies.
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Registered trials
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