Evidence map›Paper›PMID 42212147›Full record

ArticleFrontiers in immunology2026

Anti-interferon-γ autoantibody-associated adult-onset immunodeficiency with occult immunological abnormalities and sequential intracellular infections: a case report.

Xiran Zhou, Panjie Hu, Qingxia Fu, Huanchang Chen, Juan Pan, Endian Sun, Shiyi Shi, Jianzhong Ye, Deyi Zhao, Tieli Zhou and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiran Zhou *Wenzhou Medical University, Wenzhou, Zhejiang, China.
Panjie Hu *Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qingxia FuDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Huanchang ChenDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Juan PanDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Endian SunDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shiyi ShiSchool of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jianzhong YeDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Deyi ZhaoSchool of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Tieli ZhouDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lijiang ChenDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset immunodeficiency associated with anti-interferon-γ (IFN-γ) autoantibodies (AIGA) is a rare immune disorder that neutralizes IFN-γ activity and compromises defense against intracellular pathogens. It is predominantly reported in Southeast Asia and predisposes affected individuals to recurrent and multiple intracellular bacterial infections, which can be life-threatening. As a "silent disruptor," AIGA often go unnoticed due to their insidious nature, leading to a lack of sufficient clinical awareness. This report presents the case of a 59-year-old male patient from Wenzhou, Zhejiang Province, China, who experienced multiple severe infections over one year. These included disseminated bloodstream infection caused by

Indexed as

AutoantibodiesImmunologic Deficiency SyndromesInterferon-gammaHumansLegionella pneumophilaMaleMiddle AgedOsteomyelitisRituximabTalaromycesAutoantibodiesInterferon-gammaRituximabanti-interferon-γ autoantibodiescase reportintracellular infectionLegionella pneumophilamultiple infectionssalmonella enteritidisTalaromyces marneffei

Identifiers

PMID42212147
PMCPMC13212536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.