Evidence map›Paper›PMID 42212132›Full record

Observational studyFrontiers in immunology2026

Clinical characteristics and long-term prognosis of talaromycosis in children with novel and reported inborn errors of immunity.

Qian Lu, Xianghui Li, Zhiwen Jiang, Tiantian Li, Bingkun Li, Lan Huang, Qihua Huang, Dongmei Hu, Chunying Lv, Guoqun Liu and 22 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Qian Lu *Department of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xianghui Li *Department of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhiwen Jiang *Department of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Tiantian LiDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Bingkun LiDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lan HuangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Qihua HuangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Dongmei HuDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Chunying LvDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guoqun LiuDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jialing ZhongDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jingjing LinDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Liuwei LiaoDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Qianfeng QinDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Sha QinDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Haotian ShaoDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhiyi WangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiuying LiDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li JiangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xinyu ZhangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lili WeiDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jiarong LiangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Dongyan ZhengDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shuangjie WangDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Weixuan WuDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Kaisu PanDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yanqing ZhengGuangxi Key Laboratory of Mycosis Prevention and Treatment, Nanning, Guangxi, China.
Yanning LiSchool of Public Health Guangxi Medical University, Nanning, China.
Qing TangDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Min JiangDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wanqing LiaoGuangxi Scientific and Technological Innovation Cooperation Base of Mycosis Prevention and Control, Nanning, China.
Cunwei CaoDepartment of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Little is known about the long-term prognosis of patients with talaromycosis and inborn errors of immunity (IEI). Objective: We aimed to evaluate the clinical characteristics and long-term outcomes of talaromycosis in children with IEI on a 13-year cohort study. Main outcomes and measures: An observational study was conducted on pediatric patients with talaromycosis at tertiary hospitals in southern China during 2012 to 2024. Data on demographic information, clinical features, immunological characteristics, genetic tests, antifungal treatment, and long-term prognosis were collected for analysis. Results: Among the 329 patients with talaromycosis without HIV, children accounted for 7%. 100% children with talaromycosis were diagnosed as IEI, and a total of 18 children were finally enrolled. All children were identified with IEI, including five novel genetic defects ( Conclusions and relevance: Talaromycosis serves as an early warning indicator for IEI in HIV-uninfected children. Treatment and long-time management remain a challenge. Besides, long lasting anti-fungal and immune boosting therapy may be necessary, while HSCT intervention could provide potential benefits.

Indexed as

Genetic Diseases, InbornMycosesAntifungal AgentsChildChild, PreschoolFemaleHumansInfantMalePrognosisAntifungal AgentschildrenHIV-uninfectedinborn errors of immunitymanagementprognosistalaromycosis

Identifiers

PMID42212132
PMCPMC13212303

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