Evidence map›Paper›PMID 42212114›Full record

ArticleACS catalysis2025

Ni/Ti Dual Catalyzed Cross-Electrophile Coupling Between Unactivated Alkyl Chlorides and Aryl Halides.

Devi Oniani, Xiaofan Jia, Emily L Mane, David J Charboneau, Jasmine L Chow, Nilay Hazari, Haotian Huang, Maizie Lee, Brandon Q Mercado, Mycah R Uehling and 1 more

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In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Ring-opening decarbonylative C(spChemical science · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Devi OnianiDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Xiaofan JiaDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Emily L ManeDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
David J CharboneauDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Jasmine L ChowDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Nilay HazariDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Haotian HuangDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Maizie LeeMerck & Co., Inc., Discovery Chemistry, HTE and Lead Discovery Capabilities, Rahway, New Jersey, 07065, USA.
Brandon Q MercadoDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.
Mycah R UehlingMerck & Co., Inc., Discovery Chemistry, HTE and Lead Discovery Capabilities, Rahway, New Jersey, 07065, USA.
Justin C WedalDepartment of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut, 06520, USA.

Funding

Fundamental Studies of Ni-Catalyzed Organic ReactionsR35GM148260 · NIGMS · YALE UNIVERSITY · PI Nilay Hazari · 2023 to 2026
$1.9M
NIGMS NIH HHS R35 GM148260
6 · The paper itself

Abstract

A dual Ni/Ti-catalyzed method for cross-electrophile coupling (XEC) of primary and secondary alkyl chlorides and aryl halides is described. This is a rare example of a thermal XEC reaction that directly couples unactivated alkyl chlorides, which are valuable substrates because of their accessibility and stability. Mechanistic studies indicate that the Ti catalyst, Cp*

Indexed as

Alkyl chloride activationCross electrophile couplingDual catalysisMechanistic studiesNi catalysisRadical generationTi catalysis

Identifiers

PMID42212114
PMCPMC13215692

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.