Evidence map›Paper›PMID 42212113›Full record

ArticleMolecular genetics and metabolism reports2026

Body composition in adults with phenylketonuria: A 5 years follow-up study.

Bianca Fasolo Franceschetto, Yannick Moutapam-Ngamby-Adriaansen, Nathalie Tressel, Arnaud de Luca, Manuel Schiff, Soraia Poloni, Ida Vanessa D Schwartz, François Maillot

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Article in Molecular genetics and metabolism reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianca Fasolo FranceschettoFederal University of Rio Grande do Sul - Postgraduate Program in Medicine: Medical Sciences, Porto Alegre, RS, Brazil.
Yannick Moutapam-Ngamby-AdriaansenDepartment of Internal Medicine, University Hospital of Tours, Tours, France.
Nathalie TresselDepartment of Internal Medicine, University Hospital of Tours, Tours, France.
Arnaud de LucaDepartment of Nutrition, University Hospital of Tours, Tours, France.
Manuel SchiffReference Center for Inborn Errors of Metabolism, Necker University Hospital, APHP and University of Paris Cité, Filière G2M, MetabERN, INSERM UMRS 1163, Institut Imagine Paris, France.
Soraia PoloniDepartment of Nutrition, Porto Alegre Clinical Hospital, Porto Alegre, RS, Brazil.
Ida Vanessa D SchwartzFederal University of Rio Grande do Sul - Postgraduate Program in Medicine: Medical Sciences, Porto Alegre, RS, Brazil.
François MaillotDepartment of Internal Medicine, University Hospital of Tours, Tours, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This longitudinal study evaluated body composition in 24 early-treated adults with PKU using Dual-Energy X-ray Absorptiometry (DXA). At baseline, eutrophy, overweight, and obesity were found in 9, 9, and 6 patients, respectively. After 5 years, sixteen patients presented reduction in lean mass and an increase in body fat percentage, despite stable weight and BMI. These adverse changes may be linked to the phenylalanine restricted diet. These findings highlight the need for monitoring and targeted interventions to mitigate body composition deterioration in this population.

Indexed as

Body compositionPhenyalanine-restricted diet, adultsPhenylketonuria

Identifiers

PMID42212113
PMCPMC13214346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.