ArticleJACS Au2026
Caspofungin-Based Red-Emissive Probes for Fluorescent Imaging of Pathogenic Fungi.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Fungal infections are an often-neglected cause of morbidity worldwide, while their inaccurate and often inconclusive diagnosis indirectly promotes high morbidity and the development of antimicrobial resistance. Here, the clinically used semisynthetic echinocandin antifungal caspofungin was selectively conjugated to red-emitting fluorescent dyes to develop new optical imaging probes for fungal detection. The probes were characterized using established 2D NMR techniques to determine the specific position of the fluorophore on the peptide backbone, and both isomers demonstrated selective labeling of pathogenic fungal strains with similar efficacy. Selective multiplexed imaging of target species was achieved in a co-culture of fungi and bacteria, including when using benchtop imaging platforms.
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