Evidence map›Paper›PMID 42212063›Full record

ArticleJACS Au2026

Enzyme-Induced Supramolecular Proteolysis-Targeting Chimeras Enable Tumor-Targeted Protein Degradation.

Chunjing Liang, Xiaoqing Ma, Xiaxue Chen, Cunxun Dai, Xiaodi Sun, Jie Li, Ruyun Dong, Peng Dong, Ming Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunjing LiangSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.ORCID https://orcid.org/0009-0006-4387-2548
Xiaoqing MaSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.
Xiaxue ChenBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China.
Cunxun DaiSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.
Xiaodi SunSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.
Jie LiSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.
Ruyun DongSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.
Peng DongSchool of Medical Imaging, Shandong Second Medical University, Weifang 261053, China.
Ming WangBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China.ORCID https://orcid.org/0000-0002-2783-9426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted protein degradation (TPD) using proteolysis-targeting chimeras (PROTACs) offers a promising approach to modulating intracellular protein homeostasis and eliminating disease-associated proteins. However, conventional PROTACs often exhibit limited control over tissue and spatial selectivity for

Indexed as

ferroptosisin situ assemblySupTACtargeted protein degradationtumor

Identifiers

PMID42212063
PMCPMC13213516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.