Evidence map›Paper›PMID 42212053›Full record

ArticleJournal of orthopaedic translation2026

A novel non-invasive approach monitoring skeletal stem cell function through

Zan Li, Dongsheng Zhang, Dilibire Adili, Jie Han, Zhenwen Xie, Qianhe Xu, Lixin Tian, Guangfa Wang, Guolin Wang, Peipei Wang and 2 more

Abstract read
In one paragraph

Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zan LiDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Dongsheng ZhangDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Dilibire AdiliDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Jie HanDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Zhenwen XieDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Qianhe XuDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Lixin TianThe State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou, China.
Guangfa WangDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Guolin WangDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Peipei WangDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.
Xinhui SuDepartment of Nuclear Medicine & PET Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 311113, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fracture nonunion remains a major clinical challenge and is closely associated with dysfunction of osteogenic-lineage cells and their progenitors, skeletal stem cells (SSCs). However, conventional clinical approaches lack the specificity required to assess SSC functional status Methods: We first integrated RNA sequencing with FDA-approved radiotracers, to demonstrate Results: By integrating SSC RNA sequencing with FDA-approved or radiotracers in III/IV phase clinical trials, we identified CXCR4 as a promising diagnostic target and evaluated SSC activity using Conclusion: Together, these findings establish CXCR4-targeted Translational potential of this article: This study facilitates the translation of fundamental skeletal stem cell (SSC) biology into clinical decision-making by repurposing the CXCR4-targeting radiotracer

Indexed as

8F-pentixaforBone regenerationCXCR4Fracture healingPET imagingSkeletal stem cells

Identifiers

PMID42212053
PMCPMC13214306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.