ReviewGynecology and pelvic medicine2024
Cancer of the uterine cervix: a narrative review.
Review in Gynecology and pelvic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- KLK5 and KLK7 drive cervical carcinoma via KLK14-dependent RhoA and NF-κB pathways.Translational oncology · 2025Article
- Downregulation ofTranslational cancer research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Uterine cervical cancer remains a major global public health challenge. This narrative review aims to provide a comprehensive overview of the epidemiology, pathogenesis, histological classification, screening, diagnostic approaches, treatment, and prevention of cervical cancer. Methods: We searched MEDLINE, Google Scholar, and Scopus for publications in English without date limits and using the search terms "cervical cancer" AND "human papillomavirus" AND "screening" OR "staging" OR "diagnosis" OR "microbiome" OR "treatment" OR "HPV DNA test". We also used references from the texts retrieved via our literature searches. Key Content and Findings: Cervical cancer has several histological types, with squamous cell carcinoma being the most common, followed by adenocarcinoma. Human papillomavirus (HPV) is considered the main, but not exclusive, player in oncogenesis. The mechanisms of cancer development are well understood, especially the roles of E6 and E7. The vaginal microbiome is an essential cofactor in this process. Prevention can be via either primary (vaccination) or secondary (screening) intervention. The Papanicolaou test and HPV DNA test are the primary screening tools. Index screening cases must undergo colposcopy and biopsy to identify high-grade squamous intraepithelial lesions (true precancerous lesions), and such cases must be treated according to guidelines. However, if an invasive cancer occurs, it must be staged to define the treatment. Conclusions: The pathogenesis of cervical cancer has been studied extensively, and various well-defined forms of prevention have been devised. However, it is still prevalent, especially in developing countries. The present review is vital for updating knowledge and helping in the fight against this disease that kills so many women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.