ArticleGynecology and pelvic medicine2025
A newly identified allelic mutation c.110C>T in the
Article in Gynecology and pelvic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Adenomyosis (AM) is a common benign gynecological disease, defined by the presence of endometrial glands and stroma deep within the myometrium, which is associated with hypertrophy and hyperplasia of the adjacent myometrium. It mainly occurs in women of reproductive age and rarely exhibits invasive growth patterns in young women. This study presents two rare cases of diffuse AM in two young females, with the same Case Description: Case one, a 29-year-old female, G0P0, the patient experiences repeated contact bleeding, increased menstrual flow, and abdominal pain. Ultrasound examination revealed a weak echo area in the uterine cavity, and subsequent surgical intervention revealed extensive necrotic tissue resembling rotten fish in the uterine cavity, extending to more than half of the muscle layer. Case two, a 26-year-old female, G0P0, the menstrual flow increased for 4 years without any other symptoms. Computed tomography (CT) imaging demonstrated a space-occupying lesion within the uterine cavity, with uneven density and enhancement, and an ill-defined border with the anterior uterine wall muscle. During the procedure, a block of tissue approximately 8cm in diameter was observed on the right uterine wall, accompanied by several small polypoid protrusions nearby. Histopathological examination of two cases revealed multiple endometrial polyps, characterized by widespread distribution of endometrial glands and stroma within the uterine muscle wall, with some glands showing dilation and a dense increase in spiral arterioles within the stroma. The deepest lesions are all close to the uterine serosa. The final diagnosis was extensive AM. Next-generation sequencing revealed a Conclusions: The study first identified a mutation of
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